Analysis Tools
immune system
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• in a DSS-induced model of colitis, mice lose less weight than wild-type mice starting at day 5 after disease induction
• histological analysis reveals only mild damage occurring in the epithelial of the colon compared to wild-type mice that have lesions in their epithelium
• infiltrates in the lamina propia are greatly reduced
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• there are increased levels of antigen-specific IgG2a in the sera of mice after immunization
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• CD4 T cells from immunized mice do not produce IL-17F
• however, IL17A production is normal
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• mice have a moderately improved recovery from EAE compared to wild-type mice
• the number of infiltrating CD4 T cells in the central nervous system is greatly reduced compared to wild-type mice
• expression of the chemokines CCL2, CCL7, and CXCL1 is greatly reduced in the CNS during EAE
• there is an increase in IFN-gamma production by T cells in the spleen following induction of EAE
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• substantially less neutrophils are recruited to the airway compared to wild-type mice in a allergic model of acute inflammation
• CXCL5 production is reduced in the lungs of these mice during this allergic model
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• in a chronic asthma model, more eosinophils are found in the bronchoalveolar fluid than in wild-type mice in the same model
• there is increased expression of Th2 cytokines IL-4, IL-5, IL-13 by activated T cells in the lung lymph nodes and spleens of mice in the asthma model
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digestive/alimentary system
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• in a DSS-induced model of colitis, mice lose less weight than wild-type mice starting at day 5 after disease induction
• histological analysis reveals only mild damage occurring in the epithelial of the colon compared to wild-type mice that have lesions in their epithelium
• infiltrates in the lamina propia are greatly reduced
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hematopoietic system
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• there are increased levels of antigen-specific IgG2a in the sera of mice after immunization
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