Analysis Tools
immune system
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• in a DSS-induced model of colitis, mice lose more weight than wild-type mice starting at day 5 after disease induction
• mice also have more severe diarrhea, more blood in the stool with the increased weight loss
• histological analysis revels severe epithelial lesions and crypt basal separation
• infiltrates in the lamina propia are greatly increased
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• there is about a 20% decrease in the number of CD4 T cells found in the spleen
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• there are less amounts of antigen specific antibody in the sera in mice after immunization
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• there are less amounts of antigen specific antibody in the sera in mice after immunization
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• there are less amounts of antigen specific antibody in the sera in mice after immunization
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• there are less amounts of antigen specific antibody in the sera in mice after immunization
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• CD4 T cells from immunized mice do not produce IL-17A and have reduced production of IL-17F
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• mice are significantly delayed in disease onset and progression with incidence peaking at 60% compared to 100% in wild-type mice
• the number of infiltrating CD4 T cells in the central nervous system is greatly reduced compared to wild-type mice
• expression of the chemokines CCL2, CCL7, and CXCL1 is greatly reduced in the CNS during EAE
• there is an increase in IFN-gamma production by T cells in the spleen following induction of EAE
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• in a chronic asthma model, less eosinophils are found in the bronchoalveolar fluid than in wild-type mice in the same model
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hematopoietic system
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• there is about a 20% decrease in the number of CD4 T cells found in the spleen
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• there are less amounts of antigen specific antibody in the sera in mice after immunization
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• there are less amounts of antigen specific antibody in the sera in mice after immunization
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• there are less amounts of antigen specific antibody in the sera in mice after immunization
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• there are less amounts of antigen specific antibody in the sera in mice after immunization
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digestive/alimentary system
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• in a DSS-induced model of colitis, mice lose more weight than wild-type mice starting at day 5 after disease induction
• mice also have more severe diarrhea, more blood in the stool with the increased weight loss
• histological analysis revels severe epithelial lesions and crypt basal separation
• infiltrates in the lamina propia are greatly increased
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