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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Aicdatm2Mnz
targeted mutation 2, Michel C Nussenzweig
MGI:3796170
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Aicdatm2Mnz/Aicdatm2Mnz B6.Cg-Aicdatm2Mnz MGI:3809681
ht2
 		Aicdatm1Hon/Aicdatm2Mnz involves: C57BL/6 * CBA MGI:3809682


Genotype
MGI:3809681
hm1
Allelic
Composition		 Aicdatm2Mnz/Aicdatm2Mnz
Genetic
Background		 B6.Cg-Aicdatm2Mnz
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aicdatm2Mnz mutation (1 available); any Aicda mutation (57 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
chromosomal instability ( J:136224 )
• B cells exhibit an increase in reciprocal chromosome translocations between Igh and Myc compared to in Aicdatm1Hon heterozygotes and wild-type mice

immune system
immune system phenotype ( J:136224 )
N
• class switching and somatic hypermutation rates are normal




Genotype
MGI:3809682
ht2
Allelic
Composition		 Aicdatm1Hon/Aicdatm2Mnz
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aicdatm1Hon mutation (7 available); any Aicda mutation (57 available)
Aicdatm2Mnz mutation (1 available); any Aicda mutation (57 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
chromosomal instability ( J:136224 )
• B cells exhibit a 3- to 6-fold increase in reciprocal chromosome translocations between Igh and Myc compared to in Aicdatm1Hon heterozygotes

immune system
immune system phenotype ( J:136224 )
N
• mice exhibit normal B cell development in the bone marrow, peripheral B cell numbers in the spleen, serum immunoglobulin isotypes, class switching, and somatic hypermutation rates




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory