About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Irak2tm1Aki
targeted mutation 1, Shizuo Akira
MGI:3796171
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Irak2tm1Aki/Irak2tm1Aki involves: 129/Sv * C57BL/6 MGI:3807960
cx2
 		Irak1tm1Jth/Y
Irak2tm1Aki/Irak2tm1Aki 		involves: 129/Sv * C57BL/6 MGI:3807961


Genotype
MGI:3807960
hm1
Allelic
Composition		 Irak2tm1Aki/Irak2tm1Aki
Genetic
Background		 involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irak2tm1Aki mutation (0 available); any Irak2 mutation (58 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal macrophage physiology ( J:136290 )
• production of Il6, Tnf and the chemokine KC is abrogated in macrophages after LPS or CpG DNA stimulation
decreased susceptibility to endotoxin shock ( J:136290 )
• mice are completely resistant to septic shock induced by LPS or CpG DNA unlike wild-type which succumb to shock

hematopoietic system
abnormal macrophage physiology ( J:136290 )
• production of Il6, Tnf and the chemokine KC is abrogated in macrophages after LPS or CpG DNA stimulation




Genotype
MGI:3807961
cx2
Allelic
Composition		 Irak1tm1Jth/Y
Irak2tm1Aki/Irak2tm1Aki
Genetic
Background		 involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irak1tm1Jth mutation (0 available); any Irak1 mutation (16 available)
Irak2tm1Aki mutation (0 available); any Irak2 mutation (58 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal macrophage physiology ( J:136290 )
• thioglcollate-elicited peritoneal macrophages show impaired production of Il6, Tnf and the chemokine KC, upon stimulation by TLR ligands such as LPS or CpG DNA, but response to poly(I:C) is comparable to wild-type
abnormal dendritic cell physiology ( J:136290 )
• cytokine production in response to TLR ligands such as LPS or CpG DNA is defective
decreased susceptibility to endotoxin shock ( J:136290 )
• after challenge with LPS or CpG DNA together with D-galactosamine, no mutants died in contrast to 100% mortality of wild-type to endotoxic shock

hematopoietic system
abnormal macrophage physiology ( J:136290 )
• thioglcollate-elicited peritoneal macrophages show impaired production of Il6, Tnf and the chemokine KC, upon stimulation by TLR ligands such as LPS or CpG DNA, but response to poly(I:C) is comparable to wild-type




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory