All Phenotypes Klf5<Gt(XB751)Byg> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Klf5^Gt(XB751)Byg/Klf5^Gt(XB751)Byg	B6.129P2-Klf5^Gt(XB751)Byg	MGI:3809589
ht2	Klf5^Gt(XB751)Byg/Klf5⁺	B6.129P2-Klf5^Gt(XB751)Byg	MGI:3809590

Allelic Composition	Klf5^Gt(XB751)Byg/Klf5^Gt(XB751)Byg
Genetic Background	B6.129P2-Klf5^Gt(XB751)Byg

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Klf5^Gt(XB751)Byg mutation (0 available); any Klf5 mutation (37 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality before implantation, complete penetrance ( J:168150 )

• embryos arrested at the blastocyst stage

• heterozygous intercrosses revealed no null embryos between E6.5 and E8.5

embryo

decreased inner cell mass proliferation ( J:168150 )

• in mutant embryos, both the TE and ICM lineages failed to expand normally between the morula and blastocyst stages

decreased trophectoderm cell proliferation ( J:168150 )

• in mutant embryos, both the TE and ICM lineages failed to expand normally between the morula and blastocyst stages

failure of blastocyst to hatch from the zona pellucida ( J:168150 )

• morulae cultured failed to hatch embryos and eventually collapsed

absent blastocoele ( J:168150 )

• the majority of E3.5 mutant embryos had either no cavity or a small cavity

cellular

decreased inner cell mass proliferation ( J:168150 )

• in mutant embryos, both the TE and ICM lineages failed to expand normally between the morula and blastocyst stages

decreased trophectoderm cell proliferation ( J:168150 )

• in mutant embryos, both the TE and ICM lineages failed to expand normally between the morula and blastocyst stages

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

abnormal large intestine crypts of Lieberkuhn morphology ( J:136125 )

• crypt heights in the distal colon are reduced by 11% compared to wild-type controls

• the increase in crypt heights induced in response to C. rodentium infection is 21% lower compared to infected wild-type controls

• the hyperproliferative response of crypt epithelial cells induced in response to C. rodentium infection is reduced compared to infected wild-type controls

• however, no difference in the number of apoptotic cells is seen in infected or uninfected mice compared to controls

immune system

abnormal response to infection ( J:136125 )

• the increase in dital coloncrypt heights induced in response to C. rodentium infection is 21% lower compared to infected wild-type controls

• the hyperproliferative response of distal colon crypt epithelial cells induced in response to C. rodentium infection is reduced compared to infected wild-type controls

• however, no difference in the number of apoptotic cells in distal colon crypts is seen in infected or uninfected mice compared to controls

endocrine/exocrine glands

abnormal large intestine crypts of Lieberkuhn morphology ( J:136125 )

• crypt heights in the distal colon are reduced by 11% compared to wild-type controls

• the increase in crypt heights induced in response to C. rodentium infection is 21% lower compared to infected wild-type controls

• the hyperproliferative response of crypt epithelial cells induced in response to C. rodentium infection is reduced compared to infected wild-type controls

• however, no difference in the number of apoptotic cells is seen in infected or uninfected mice compared to controls

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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