Phenotypes associated with this allele

• Allele Symbol: Tg(Hoxb3-cre)1Pkht
• Allele Name: transgene insertion 1, Paul Kwong Hang Tam
• Allele ID: MGI:3796197
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Tg(CAG-Bgeo/ALPP)1Lbe/0 Tg(CAG-en/Hoxb5,-EGFP)#Vchl/0 Tg(Hoxb3-cre)1Pkht/0	involves: 129S1/Sv * 129X1/SvJ	MGI:5749827
cn2	Tg(CAG-en/Hoxb5,-EGFP)#Vchl/0 Tg(Hoxb3-cre)1Pkht/0	Not Specified	MGI:5749826

Genotype
MGI:5749827

cn1

• Allelic Composition: Tg(CAG-Bgeo/ALPP)1Lbe/0; Tg(CAG-en/Hoxb5,-EGFP)#Vchl/0; Tg(Hoxb3-cre)1Pkht/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

abnormal enteric neural crest cell migration ( J:136122 )

• retarded migration that either colonizes the proximal half of the small intestine or have just entered the small intestine

cellular

abnormal enteric neural crest cell migration ( J:136122 )

• retarded migration that either colonizes the proximal half of the small intestine or have just entered the small intestine

Genotype
MGI:5749826

cn2

• Allelic Composition: Tg(CAG-en/Hoxb5,-EGFP)#Vchl/0; Tg(Hoxb3-cre)1Pkht/0
• Genetic Background: Not Specified

mortality/aging

postnatal lethality, incomplete penetrance ( J:136122 )

• in one mouse

digestive/alimentary system

abnormal colon morphology ( J:136122 )

• constricted in one mouse

aganglionic megacolon ( J:136122 )

• in one mouse

enlarged duodenum ( J:136122 )

• due to food bolus in one mouse

abnormal ileum morphology ( J:136122 )

• lacking ganglia in one mouse

ileum atresia ( J:136122 )

• in one mouse

distended jejunum ( J:136122 )

• due to food bolus in one mouse

abnormal intestinal transit time ( J:136122 )

• longer transit time

growth/size/body

postnatal growth retardation ( J:136122 )

• in one mouse

distended abdomen ( J:136122 )

• in one mouse

cellular

abnormal enteric neural crest cell migration ( J:136122 )

• defective migration into the small intestine

• however, neural crest cells are abundant in the stomach and no increase in apoptosis is detected

embryo

abnormal enteric neural crest cell migration ( J:136122 )

• defective migration into the small intestine

• however, neural crest cells are abundant in the stomach and no increase in apoptosis is detected

nervous system

abnormal enteric neuron morphology ( J:136122 )

• fewer numbers in the proximal and distal small intestines than in wild-type