Analysis Tools|
Allele Symbol Allele Name Allele ID |
Neurog3tm1(Neurog3,cre/ERT)Ggu targeted mutation 1, Guoqiang Gu MGI:3796205 |
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| Summary |
5 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• after tamoxifen treatment, beta cell function is disrupted compared to in wild-type mice
• however, beta cells exhibit normal cell division and cell death
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• in female mice 10 weeks after tamoxifen treatment
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in male mice 4 weeks after tamoxifen treatment
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• in male mice 12 weeks after tamoxifen treatment
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• 12 weeks after tamoxifen treatment, postglucose-challenge-serum-insulin levels are decreased unlike in similarly treated wild-type mice
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• in female mice 2 and 3 months after tamoxifen treatment and in male mice 12 weeks after tamoxifen treatment
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at 6 weeks compared to in Neurog3tm1(cre/ESR1)Ggu/Neurog3tm1.1(cre/ESR1)Ggu mice
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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