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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Neurog3tm1.1(cre/ERT)Ggu
targeted mutation 1.1, Guoqiang Gu
MGI:3796207
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Neurog3tm1.1(cre/ERT)Ggu/Neurog3+ involves: 129S6/SvEvTac MGI:3850074
cn2
 		Neurog3tm1(Neurog3,cre/ERT)Ggu/Neurog3tm1.1(cre/ERT)Ggu involves: 129S6/SvEvTac MGI:3850073
cn3
 		Neurog3tm1.1(cre/ERT)Ggu/Neurog3+
Pdx1tm1Macd/Pdx1+
Tg(tetO-Myt1)2Ggu/0 		involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ MGI:3809541
cn4
 		Neurog3tm1(Neurog3,cre/ERT)Ggu/Neurog3tm1.1(cre/ERT)Ggu
Tg(Pdx1-cre/Esr1*)1Mga/0 		involves: 129S6/SvEvTac MGI:3850077
cn5
 		Neurog3tm1(Neurog3,cre/ERT)Ggu/Neurog3tm1.1(cre/ERT)Ggu
Tg(Ins2-cre)25Mgn/0 		involves: 129S6/SvEvTac * C57BL/6 * DBA MGI:3850075


Genotype
MGI:3850074
ht1
Allelic
Composition		 Neurog3tm1.1(cre/ERT)Ggu/Neurog3+
Genetic
Background		 involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Neurog3tm1.1(cre/ERT)Ggu mutation (0 available); any Neurog3 mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism




Genotype
MGI:3850073
cn2
Allelic
Composition		 Neurog3tm1(Neurog3,cre/ERT)Ggu/Neurog3tm1.1(cre/ERT)Ggu
Genetic
Background		 involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Neurog3tm1.1(cre/ERT)Ggu mutation (0 available); any Neurog3 mutation (19 available)
Neurog3tm1(Neurog3,cre/ERT)Ggu mutation (0 available); any Neurog3 mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism




Genotype
MGI:3809541
cn3
Allelic
Composition		 Neurog3tm1.1(cre/ERT)Ggu/Neurog3+
Pdx1tm1Macd/Pdx1+
Tg(tetO-Myt1)2Ggu/0
Genetic
Background		 involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Neurog3tm1.1(cre/ERT)Ggu mutation (0 available); any Neurog3 mutation (19 available)
Pdx1tm1Macd mutation (1 available); any Pdx1 mutation (35 available)
Tg(tetO-Myt1)2Ggu mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal pancreatic islet morphology ( J:136131 )
• fewer cells are induced to produce glucagons than in Pdx1tm1Macd/Pdx1+ Tg(tetO-Neurog3)8Ggu mice




Genotype
MGI:3850077
cn4
Allelic
Composition		 Neurog3tm1(Neurog3,cre/ERT)Ggu/Neurog3tm1.1(cre/ERT)Ggu
Tg(Pdx1-cre/Esr1*)1Mga/0
Genetic
Background		 involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Neurog3tm1.1(cre/ERT)Ggu mutation (0 available); any Neurog3 mutation (19 available)
Neurog3tm1(Neurog3,cre/ERT)Ggu mutation (0 available); any Neurog3 mutation (19 available)
Tg(Pdx1-cre/Esr1*)1Mga mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased circulating glucose level ( J:150074 )
• in male mice 4 weeks after tamoxifen treatment
hyperglycemia ( J:150074 )
• in male mice 12 weeks after tamoxifen treatment
abnormal circulating insulin level ( J:150074 )
• 12 weeks after tamoxifen treatment, postglucose-challenge-serum-insulin levels are decreased unlike in similarly treated wild-type mice
impaired glucose tolerance ( J:150074 )
• in female mice 2 and 3 months after tamoxifen treatment and in male mice 12 weeks after tamoxifen treatment




Genotype
MGI:3850075
cn5
Allelic
Composition		 Neurog3tm1(Neurog3,cre/ERT)Ggu/Neurog3tm1.1(cre/ERT)Ggu
Tg(Ins2-cre)25Mgn/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Neurog3tm1.1(cre/ERT)Ggu mutation (0 available); any Neurog3 mutation (19 available)
Neurog3tm1(Neurog3,cre/ERT)Ggu mutation (0 available); any Neurog3 mutation (19 available)
Tg(Ins2-cre)25Mgn mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased circulating glucose level ( J:150074 )
• at 6 weeks compared to in Neurog3tm1(cre/ESR1)Ggu/Neurog3tm1.1(cre/ESR1)Ggu mice




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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory