All Phenotypes Cebpa<tm8.1Nerl> MGI Mouse

mortality/aging

premature death ( J:136134 )

• mice die after 9 to 14 months

postnatal lethality, incomplete penetrance ( J:136134 )

• fewer than expected mice survive to weaning

hematopoietic system

enlarged spleen ( J:136134 )

abnormal definitive hematopoiesis ( J:136134 )

• mice exhibit bone marrow failure with the replacement of normal hematopoietic cells with Mac1+Gr1^lo and high myeloid blasts counts

abnormal common myeloid progenitor cell morphology ( J:136134 )

• bone marrow myeloid progenitor cells exhibit an increase in proliferative capacity compared to in wild-type mice

• myeloid progenitor cells exhibit increased self-renewal capacity compared to wild-type cells

extramedullary hematopoiesis ( J:136134 )

• mice exhibit ectopic myelopoiesis

decreased hematocrit ( J:136134 )

• in late stages

abnormal leukocyte morphology ( J:136134 )

• in late stages, mice exhibit decreased leukocyte counts

abnormal myeloid leukocyte morphology ( J:136134 )

• at 2 months of age, peripheral blood contains lower numbers of myeloid cells compared to in wild-type mice

abnormal granulocyte morphology ( J:136134 )

• mice exhibit a progressive block in granulocyte differentiation at an intermediate stage hyperproliferation

decreased granulocyte number ( J:136134 )

• at 2 months of age, mice exhibit neutropenic bone marrow, low numbers of Mac1+Gr1+ cells and few granulocytes

decreased neutrophil cell number ( J:136134 )

• at 2 months of age

decreased monocyte cell number ( J:136134 )

neoplasm

increased leukemia incidence ( J:136134 )

• mice develop acute myeloid leukemia

• normal hematopoiesis is displaced by malignant myeloid cells

• malignant cells are transplantable in the absence of phenotypic hematopoietic stem cells

• the only karyotype abnormality observed in tumor cells is the loss of the Y chromosome

liver/biliary system

liver inflammation ( J:136134 )

• mice exhibit massive hematopoietic infiltrates with remaining hepatocytes scattered compared to in wild-type mice

decreased hepatocyte number ( J:136134 )

liver failure ( J:136134 )

homeostasis/metabolism

hypoglycemia ( J:136134 )

• at birth

immune system

enlarged spleen ( J:136134 )

abnormal leukocyte morphology ( J:136134 )

• in late stages, mice exhibit decreased leukocyte counts

abnormal myeloid leukocyte morphology ( J:136134 )

• at 2 months of age, peripheral blood contains lower numbers of myeloid cells compared to in wild-type mice

abnormal granulocyte morphology ( J:136134 )

• mice exhibit a progressive block in granulocyte differentiation at an intermediate stage hyperproliferation

decreased granulocyte number ( J:136134 )

• at 2 months of age, mice exhibit neutropenic bone marrow, low numbers of Mac1+Gr1+ cells and few granulocytes

decreased neutrophil cell number ( J:136134 )

• at 2 months of age

decreased monocyte cell number ( J:136134 )

liver inflammation ( J:136134 )

• mice exhibit massive hematopoietic infiltrates with remaining hepatocytes scattered compared to in wild-type mice

growth/size/body

enlarged spleen ( J:136134 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
acute myeloid leukemia		DOID:9119	OMIM:601626	J:136134

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24