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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Best2tm1Dgen
targeted mutation 1, Deltagen
MGI:3796232
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Best2tm1Dgen/Best2tm1Dgen involves: C57BL/6 MGI:3809448
ht2
Best2tm1Dgen/Best2+ involves: C57BL/6 MGI:3809450


Genotype
MGI:3809448
hm1
Allelic
Composition
Best2tm1Dgen/Best2tm1Dgen
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Best2tm1Dgen mutation (0 available); any Best2 mutation (29 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• mice treated with timolol fail to exhibit a reduction in intraocular pressure unlike in similarly treated wild-type mice
• mice exhibit lower intraocular pressure compared to wild-type mice
• mice exhibit a greater reduction in intraocular pressure when treated with brinzolamide compared to similarly treated wild-type mice

taste/olfaction
N
• mice exhibit normal olfaction

digestive/alimentary system
N
• mice do not exhibit gastrointestinal distress or diarrhea

homeostasis/metabolism
• mice exhibit a greater reduction in intraocular pressure when treated with brinzolamide compared to similarly treated wild-type mice
• mice treated with timolol fail to exhibit a reduction in intraocular pressure unlike in similarly treated wild-type mice




Genotype
MGI:3809450
ht2
Allelic
Composition
Best2tm1Dgen/Best2+
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Best2tm1Dgen mutation (0 available); any Best2 mutation (29 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• mice treated with timolol fail to exhibit a reduction in intraocular pressure unlike in similarly treated wild-type mice
• mice exhibit a greater reduction in intraocular pressure when treated with brinzolamide compared to similarly treated wild-type mice

homeostasis/metabolism
• mice exhibit a greater reduction in intraocular pressure when treated with brinzolamide compared to similarly treated wild-type mice
• mice treated with timolol fail to exhibit a reduction in intraocular pressure unlike in similarly treated wild-type mice





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory