Phenotypes associated with this allele

• Allele Symbol: Suz12^Plt8
• Allele Name: platelet 8
• Allele ID: MGI:3796426
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Suz12^Plt8/Suz12^+	involves: 129 * C57BL/6	MGI:6116287
ht2	Suz12^Gt(Betageo)1Khe/Suz12^Plt8	involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6	MGI:3796625
cx3	Mpl^tm1Wsa/Mpl^tm1Wsa Suz12^Plt8/Suz12^+	B6.Cg-Mpl^tm1Wsa Suz12^Plt8	MGI:3796621
cx4	Mpl^tm1Wsa/Mpl^tm1Wsa Suz12^Plt8/Suz12^Plt8	B6.Cg-Mpl^tm1Wsa Suz12^Plt8	MGI:3796623

Genotype
MGI:6116287

ht1

• Allelic Composition: Suz12^Plt8/Suz12⁺
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

thrombocytosis ( J:136262 )

• although not statistically significant platelet count was mildly elevated

increased leukocyte cell number ( J:136262 )

• due to an increased number of lymphocytes

• platelet volume, red cell count, and hematocrit were not affected

increased lymphocyte cell number ( J:136262 )

immune system

increased leukocyte cell number ( J:136262 )

• due to an increased number of lymphocytes

• platelet volume, red cell count, and hematocrit were not affected

increased lymphocyte cell number ( J:136262 )

Genotype
MGI:3796625

ht2

• Allelic Composition: Suz12^{Gt(Betageo)1Khe}/Suz12^Plt8
• Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

mortality/aging

preweaning lethality, complete penetrance ( J:136262 )

• no compound heterozygous animals were identified at weaning, indicating prenatal lethality

Genotype
MGI:3796621

cx3

• Allelic Composition: Mpl^tm1Wsa/Mpl^tm1Wsa; Suz12^Plt8/Suz12⁺
• Genetic Background: B6.Cg-Mpl^tm1Wsa Suz12^Plt8

hematopoietic system

abnormal thrombopoiesis ( J:136262 )

• amelioration of thrombocytopenia compared to Mpl^tm1Wsa , increased platelet cell number was significant but not to the wild-type level

abnormal bone marrow cell morphology/development ( J:136262 )

• hematopoietic stem cell number were increased in the bone marrow compared to Mpl^tm1Wsa control, but not to the wild-type level

abnormal megakaryocyte differentiation ( J:136262 )

• megakaryocyte numbers were increased in the bone marrow compared to Mpl^tm1Wsa control, but not to the wild-type level

thrombocytopenia ( J:136262 )

• thrombocytopenia of Mpl^tm1Wsa ameliorated, however platelet count is significantly lower than normal wild-type level

increased leukocyte cell number ( J:136262 )

increased lymphocyte cell number ( J:136262 )

immune system

abnormal thrombopoiesis ( J:136262 )

• amelioration of thrombocytopenia compared to Mpl^tm1Wsa , increased platelet cell number was significant but not to the wild-type level

increased leukocyte cell number ( J:136262 )

increased lymphocyte cell number ( J:136262 )

cellular

abnormal megakaryocyte differentiation ( J:136262 )

• megakaryocyte numbers were increased in the bone marrow compared to Mpl^tm1Wsa control, but not to the wild-type level

Genotype
MGI:3796623

cx4

• Allelic Composition: Mpl^tm1Wsa/Mpl^tm1Wsa; Suz12^Plt8/Suz12^Plt8
• Genetic Background: B6.Cg-Mpl^tm1Wsa Suz12^Plt8

mortality/aging

prenatal lethality, complete penetrance ( J:136262 )

• no homozygous Suz12^Plt8Hiltanimals were found, indicating prenatal lethality

• embryos homozygous for Suz12^Plt8Hilt were reduced in number at embryonic day 8.5

embryo

decreased embryo size ( J:136262 )

• embryos homozygous for Suz12^Plt8Hilt were smaller than wild-type

growth/size/body

decreased embryo size ( J:136262 )

• embryos homozygous for Suz12^Plt8Hilt were smaller than wild-type