All Phenotypes Suz12<Plt8> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Suz12^Plt8
platelet 8
MGI:3796426

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Suz12^Plt8/Suz12⁺	involves: 129 * C57BL/6	MGI:6116287
ht2	Suz12^{Gt(Betageo)1Khe}/Suz12^Plt8	involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6	MGI:3796625
cx3	Mpl^tm1Wsa/Mpl^tm1Wsa Suz12^Plt8/Suz12⁺	B6.Cg-Mpl^tm1Wsa Suz12^Plt8	MGI:3796621
cx4	Mpl^tm1Wsa/Mpl^tm1Wsa Suz12^Plt8/Suz12^Plt8	B6.Cg-Mpl^tm1Wsa Suz12^Plt8	MGI:3796623

Allelic Composition	Suz12^Plt8/Suz12⁺
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Suz12^Plt8 mutation (0 available); any Suz12 mutation (61 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

thrombocytosis ( J:136262 )

• although not statistically significant platelet count was mildly elevated

increased leukocyte cell number ( J:136262 )

• due to an increased number of lymphocytes

• platelet volume, red cell count, and hematocrit were not affected

increased lymphocyte cell number ( J:136262 )

immune system

increased leukocyte cell number ( J:136262 )

• due to an increased number of lymphocytes

• platelet volume, red cell count, and hematocrit were not affected

increased lymphocyte cell number ( J:136262 )

Allelic Composition	Suz12^{Gt(Betageo)1Khe}/Suz12^Plt8
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Suz12^{Gt(Betageo)1Khe} mutation (1 available); any Suz12 mutation (61 available)
Suz12^Plt8 mutation (0 available); any Suz12 mutation (61 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:136262 )

• no compound heterozygous animals were identified at weaning, indicating prenatal lethality

Allelic Composition	Mpl^tm1Wsa/Mpl^tm1Wsa Suz12^Plt8/Suz12⁺
Genetic Background	B6.Cg-Mpl^tm1Wsa Suz12^Plt8

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mpl^tm1Wsa mutation (1 available); any Mpl mutation (48 available)
Suz12^Plt8 mutation (0 available); any Suz12 mutation (61 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal thrombopoiesis ( J:136262 )

• amelioration of thrombocytopenia compared to Mpl^tm1Wsa , increased platelet cell number was significant but not to the wild-type level

abnormal bone marrow cell morphology/development ( J:136262 )

• hematopoietic stem cell number were increased in the bone marrow compared to Mpl^tm1Wsa control, but not to the wild-type level

abnormal megakaryocyte differentiation ( J:136262 )

• megakaryocyte numbers were increased in the bone marrow compared to Mpl^tm1Wsa control, but not to the wild-type level

thrombocytopenia ( J:136262 )

• thrombocytopenia of Mpl^tm1Wsa ameliorated, however platelet count is significantly lower than normal wild-type level

increased leukocyte cell number ( J:136262 )

increased lymphocyte cell number ( J:136262 )

immune system

abnormal thrombopoiesis ( J:136262 )

• amelioration of thrombocytopenia compared to Mpl^tm1Wsa , increased platelet cell number was significant but not to the wild-type level

increased leukocyte cell number ( J:136262 )

increased lymphocyte cell number ( J:136262 )

cellular

abnormal megakaryocyte differentiation ( J:136262 )

• megakaryocyte numbers were increased in the bone marrow compared to Mpl^tm1Wsa control, but not to the wild-type level

Allelic Composition	Mpl^tm1Wsa/Mpl^tm1Wsa Suz12^Plt8/Suz12^Plt8
Genetic Background	B6.Cg-Mpl^tm1Wsa Suz12^Plt8

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:136262 )

• no homozygous Suz12^Plt8Hiltanimals were found, indicating prenatal lethality

• embryos homozygous for Suz12^Plt8Hilt were reduced in number at embryonic day 8.5

embryo

decreased embryo size ( J:136262 )

• embryos homozygous for Suz12^Plt8Hilt were smaller than wild-type

growth/size/body

decreased embryo size ( J:136262 )

• embryos homozygous for Suz12^Plt8Hilt were smaller than wild-type

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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