Phenotypes associated with this allele

• Allele Symbol: Grid2ip^tm1.1Mmsh
• Allele Name: targeted mutation 1.1, Masayoshi Mishina
• Allele ID: MGI:3796575
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Grid2ip^tm1.1Mmsh/Grid2ip^tm1.1Mmsh	C57BL/6-Grid2ip^tm1.1Mmsh	MGI:3807244

Genotype
MGI:3807244

hm1

• Allelic Composition: Grid2ip^tm1.1Mmsh/Grid2ip^tm1.1Mmsh
• Genetic Background: C57BL/6-Grid2ip^tm1.1Mmsh

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:136382 )

N • cerebellar structure is normal in homozygotes

abnormal long-term depression ( J:136382 )

• 5 paired-stimulations of parallel fibers in conjunction with Purkinje cell depolarization induces robust long term depression (LTD) in cerebellar slices from mutants but only weak LTD in wild-type; 2 conjunctions induce robust LTD in mutants but fail to induce LTD in wild-type, while 1 conjuction induces weak LTD in mutants

• amplitudes of STD induced by 2 conjunctions in mutants are comparable to that induced by 10 conjunctions in wild-type

behavior/neurological

behavior/neurological phenotype ( J:136382 )

N • mutants show no deficits in motor coordination in thin rod or rotating rod tests

abnormal reflex ( J:136382 )

• mutants show an enhanced optokinetic response (OKR) adaptation compared to wild-type

• augmentation in adaptive increase in OKR is observed, but adaptive decrease in OKR phase lag is not seen