All Phenotypes Fzd5<tm2Nat> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Fzd5^tm2Nat
targeted mutation 2, Jeremy Nathans
MGI:3796577

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Fzd5^tm1Nat/Fzd5^tm2Nat Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * SJL	MGI:3807221
cn2	Fzd5^tm1Nat/Fzd5^tm2Nat Gt(ROSA)26Sor^{tm1(cre/ERT)Nat}/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * SJL	MGI:3807225

Allelic Composition	Fzd5^tm1Nat/Fzd5^tm2Nat Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3^{Tg(Sox2-cre)1Amc} mutation (5 available); any Edil3 mutation (43 available)
Fzd5^tm1Nat mutation (1 available); any Fzd5 mutation (33 available)
Fzd5^tm2Nat mutation (1 available); any Fzd5 mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body size ( J:136390 )

• animals exhibit 15-20% reduction in body size and weight

decreased body weight ( J:136390 )

nervous system

abnormal thalamus morphology ( J:136390 )

• parafascicular nucleus (PFN) exhibits loss of 50% of all neurons, and nearly 100% of Fzd5-expressing neurons at 8 weeks

• neurons are present in normal numbers and show normal projections to the striatum at P1, then are gradually lost during the first postnatal month

behavior/neurological

impaired coordination ( J:136390 )

• mice consistently show compromised performance in rotarod tests compared to heterozygous controls

vision/eye

retina degeneration ( J:136390 )

• mice display slow retinal degeneration

Allelic Composition	Fzd5^tm1Nat/Fzd5^tm2Nat Gt(ROSA)26Sor^{tm1(cre/ERT)Nat}/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fzd5^tm1Nat mutation (1 available); any Fzd5 mutation (33 available)
Fzd5^tm2Nat mutation (1 available); any Fzd5 mutation (33 available)
Gt(ROSA)26Sor^{tm1(cre/ERT)Nat} mutation (2 available); any Gt(ROSA)26Sor mutation (993 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal thalamus morphology ( J:136390 )

• PFN in adults displays nearly complete loss of alkaline phosphatase expressing Fzd5-null neurons by 10 days after 4HT injection and cre activation, but no loss is observed in Fzd5^tm2Nat/+, cre-positive control PFNs 8 days after 4HT treatment

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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