Analysis Tools
mortality/aging
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• some mice die shortly after birth with acrania and lack of brain tissue
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nervous system
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• cranial neural folds are everted at E12.5
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• at E12.5, mice exhibit a thickening of the forebrain neuroepithelium wall
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• at E12.5, mice exhibit degeneration of brain tissue
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• at E12.5, mice exhibit a thickening of the forebrain neuroepithelium wall
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exencephaly
(
J:136534
)
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• mice exhibit exencephaly of the midbrain due to over proliferation of neural tissue and evertion of cranial neural folds
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• hyperplastic at E12.5
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• hyperplastic at E12.5
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• hyperplastic at E12.5
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• at E12.5, an increased proliferation rate is noted in the forebrain neuroepithelium, as evidenced by the number of Ki-67-positive nuclei
• however, the proliferation rate of the hindbrain neural tube is normal
• the midbrain neuroepithelium continues to proliferate in exencephalic embryos and becomes a large convoluted mass of brain tissue protruding from the head
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craniofacial
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• reduced in size
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• absent at E14.5
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skeleton
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• reduced in size
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• absent at E14.5
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embryo
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• cranial neural folds are everted at E12.5
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• at E12.5, mice exhibit a thickening of the forebrain neuroepithelium wall
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