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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Setd7tm1Frga
targeted mutation 1, Francois Gaudet
MGI:3796607
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Setd7tm1Frga/Setd7tm1Frga involves: 129 * C57BL/6 MGI:3807473
ht2
 		Setd7tm1Frga/Setd7+ involves: 129 * C57BL/6 MGI:3807474


Genotype
MGI:3807473
hm1
Allelic
Composition		 Setd7tm1Frga/Setd7tm1Frga
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Setd7tm1Frga mutation (0 available); any Setd7 mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, incomplete penetrance ( J:136558 )
• about half die during embryogenesis, no time of lethality provided
• survivors appear normal at 4 and 12 months of age

cellular
abnormal cell cycle checkpoint function ( J:136558 )
• MEFs fail to arrest in G1 48 h after doxorubicin treatment and instead continue to proliferate
decreased sensitivity to induced cell death ( J:136558 )
• in MEFs 48 h after doxorubicin treatment

immune system
abnormal spleen physiology ( J:136558 )
• spleen cells fail to arrest in G1 48 h after doxorubicin treatment

homeostasis/metabolism
decreased physiological sensitivity to xenobiotic ( J:136558 )
• MEFs and spleen cells fail to arrest in G1 48 h after doxorubicin treatment
• an increase in apoptosis is not seen in MEFs 48 h after doxorubicin treatment unlike in controls




Genotype
MGI:3807474
ht2
Allelic
Composition		 Setd7tm1Frga/Setd7+
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Setd7tm1Frga mutation (0 available); any Setd7 mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal cell cycle checkpoint function ( J:136558 )
• MEFs fail to arrest in G1 48 h after doxorubicin treatment and instead continue to proliferate
decreased sensitivity to induced cell death ( J:136558 )
• in MEFs 48 h after doxorubicin treatment

immune system
abnormal spleen physiology ( J:136558 )
• spleen cells fail to arrest in G1 48 h after doxorubicin treatment

homeostasis/metabolism
decreased physiological sensitivity to xenobiotic ( J:136558 )
• MEFs and spleen cells fail to arrest in G1 48 h after doxorubicin treatment
• an increase in apoptosis is not seen in MEFs 48 h after doxorubicin treatment unlike in controls




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory