Phenotypes associated with this allele

• Allele Symbol: Smtnl1^tm1Tajh
• Allele Name: targeted mutation 1, Timothy A J Haystead
• Allele ID: MGI:3796616
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Smtnl1^tm1Tajh/Smtnl1^tm1Tajh	129S6.129P2-Smtnl1^tm1Tajh	MGI:3807228

Genotype
MGI:3807228

hm1

• Allelic Composition: Smtnl1^tm1Tajh/Smtnl1^tm1Tajh
• Genetic Background: 129S6.129P2-Smtnl1^tm1Tajh

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:136573 )

N • despite altered vascular physiology, capillary contacts and fatigue time is normal

abnormal blood vessel physiology ( J:136573 )

• sedentary mice exhibit aorta adaptations similar to those observed in exercised wild-type mice

decreased vasoconstriction ( J:136573 )

• following treatment with phenylephrine, the aortic ring exhibits decreased contractile force compared to in similarly treated wild-type mice

• however, mice do not exhibit decreased sensitivity to phenylephrine and tracheal rings exhibit normal vasocontriction

increased vasodilation ( J:136573 )

• following exposure to achetylcholine, sedentary mice exhibit increased vascular relaxation of the aortic ring compared to sedentary wild-type mice that was similar to the relaxation seen in exercised wild-type mice

• however, mice exhibit normal tracheal ring vasodilation

muscle

decreased vasoconstriction ( J:136573 )

• following treatment with phenylephrine, the aortic ring exhibits decreased contractile force compared to in similarly treated wild-type mice

• however, mice do not exhibit decreased sensitivity to phenylephrine and tracheal rings exhibit normal vasocontriction

increased vasodilation ( J:136573 )

• following exposure to achetylcholine, sedentary mice exhibit increased vascular relaxation of the aortic ring compared to sedentary wild-type mice that was similar to the relaxation seen in exercised wild-type mice

• however, mice exhibit normal tracheal ring vasodilation

abnormal skeletal muscle fiber type ratio ( J:136573 )

• sedentary mice exhibit an increase in the amount of type 2a fibers and a decrease in the amount of type 1b fibers that is similar to that observed in exercised wild-type mice

• further exercise does not increase the number of type 2a fibers as in wild-type mice

• however, skeletal muscle ultrastructure is normal

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:136573 )

N • despite altered vascular physiology, mice exhibit normal blood pressure and chemistries

enhanced exercise endurance ( J:136573 )

• male mice exhibit increased exercise endurance with increased time to fatigue, distance run and vertical work performed compared to wild-type mice