Phenotypes associated with this allele

• Allele Symbol: Plk3^tm1Dai
• Allele Name: targeted mutation 1, Wei Dai
• Allele ID: MGI:3796743
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Plk3^tm1Dai/Plk3^tm1Dai	involves: 129S4/SvJae * C57BL/6	MGI:3806980

Genotype
MGI:3806980

hm1

• Allelic Composition: Plk3^tm1Dai/Plk3^tm1Dai
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

abnormal tumor morphology ( J:136425 )

• tumor blood vessel density is increased compared to controls

increased tumor growth/size ( J:136425 )

• many tumors are large in size and well vascularized

increased tumor incidence ( J:136425 )

• mice over 18 months of age show enhanced tumor formation in various organ

increased liver tumor incidence ( J:136425 )

• liver cancer with bridging necrosis, dilated sinus, and congested vessels

• tumors also contain regenerative hepatocytes and active bile duct hyperplasia with mild cholestasis

increased leiomyosarcoma incidence ( J:136425 )

• most uterine tumors are leiomyosarcomas which are well circumscribed but not encapsulated

increased lung tumor incidence ( J:136425 )

• lung tumors have the highest incidence

increased lung adenocarcinoma incidence ( J:136425 )

• most lung tumors are adenocarcinomas in which the tumor cells have crowded, large, hyperchromatic nuclei

muscle

increased leiomyosarcoma incidence ( J:136425 )

• most uterine tumors are leiomyosarcomas which are well circumscribed but not encapsulated

respiratory system

increased lung tumor incidence ( J:136425 )

• lung tumors have the highest incidence

increased lung adenocarcinoma incidence ( J:136425 )

• most lung tumors are adenocarcinomas in which the tumor cells have crowded, large, hyperchromatic nuclei

liver/biliary system

increased liver tumor incidence ( J:136425 )

• liver cancer with bridging necrosis, dilated sinus, and congested vessels

• tumors also contain regenerative hepatocytes and active bile duct hyperplasia with mild cholestasis