Phenotypes associated with this allele

• Allele Symbol: Rr148^tm2Anbo
• Allele Name: targeted mutation 2, Andrea Bottaro
• Allele ID: MGI:3796984
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rr148^tm2Anbo/Rr148^tm2Anbo	involves: 129/Sv * C57BL/6 * FVB/N	MGI:3803289

Genotype
MGI:3803289

hm1

• Allelic Composition: Rr148^tm2Anbo/Rr148^tm2Anbo
• Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased immature B cell number ( J:136307 )

• the percentage of immature B cells in the bone marrow is 0.9% compared to 2.7% in the bone marrow of wild-type mice

abnormal immunoglobulin heavy chain V(D)J recombination ( J:136307 )

• there is a significant decrease in VDJ gene segment recombination at both the D-J step and the V-DJ recombination step

• over 30% of non-functional Igh alleles in B cells lack recombination of the J gene segments while all of the non-functional alleles in wild-type B cells have recombined J gene segments

• no recombination of the Igh variable gene segments occurs in the non-functional alleles of B cells compared to 40% of wild-type B cells having recombination of the non-functional Igh alleles

decreased mature B cell number ( J:136307 )

• the percentage of mature B cells in the bone marrow is 1.9% compared to 10.9% in the bone marrow of wild-type mice

• the percentage of mature B cells in the spleen is 10.5% compared to 31.1% in wild-type mice

decreased pre-B cell number ( J:136307 )

• the percentage of pre-B cells in the bone marrow is 0.3% compared to 0.9% in the bone marrow of wild-type mice

hematopoietic system

decreased immature B cell number ( J:136307 )

• the percentage of immature B cells in the bone marrow is 0.9% compared to 2.7% in the bone marrow of wild-type mice

abnormal immunoglobulin heavy chain V(D)J recombination ( J:136307 )

• there is a significant decrease in VDJ gene segment recombination at both the D-J step and the V-DJ recombination step

• over 30% of non-functional Igh alleles in B cells lack recombination of the J gene segments while all of the non-functional alleles in wild-type B cells have recombined J gene segments

• no recombination of the Igh variable gene segments occurs in the non-functional alleles of B cells compared to 40% of wild-type B cells having recombination of the non-functional Igh alleles

decreased mature B cell number ( J:136307 )

• the percentage of mature B cells in the bone marrow is 1.9% compared to 10.9% in the bone marrow of wild-type mice

• the percentage of mature B cells in the spleen is 10.5% compared to 31.1% in wild-type mice

decreased pre-B cell number ( J:136307 )

• the percentage of pre-B cells in the bone marrow is 0.3% compared to 0.9% in the bone marrow of wild-type mice