All Phenotypes Foxc1<hith> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Foxc1^hith
hole-in-the-head
MGI:3797008

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Foxc1^hith/Foxc1^hith	involves: C57BL/6J	MGI:4437877
hm2	Foxc1^hith/Foxc1^hith	involves: C57BL/6J * FVB/N	MGI:3802472
ht3	Foxc1^hith/Foxc1^tm1Blh	involves: 129S6/SvEvTac * C57BL/6J	MGI:4437878
cx4	Foxc1^hith/Foxc1^hith Tg(Rr291-lacZ)#Mekk/0	involves: C57BL/6J * FVB/N	MGI:3802474

Allelic Composition	Foxc1^hith/Foxc1^hith
Genetic Background	involves: C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxc1^hith mutation (0 available); any Foxc1 mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal neuron differentiation ( J:157301 )

• at E14.5, the number of intermediate progenitor cells is decreased compared to in wild-type mice

abnormal neuron proliferation ( J:157301 )

• at E14.5, neuron proliferation in the cortex is reduced compared to in wild-type mice

• neurons exhibit cell-cycle exit defect compared with wild-type cells

• however, transplantation of wild-type meninges increases proliferation while treatment with retinoic acid increases cell-cycle exit

abnormal forebrain morphology ( J:157301 )

• at E12.5, dorsal forebrain lengthening is observed unlike in wild-type mice

• at E14.5, the dorsal forebrain is longer and thinner than in wild-type mice

• however, treatment with all-trans retinoic acid restores forebrain morphology

abnormal cerebral cortex morphology ( J:157301 )

• at E18.5

abnormal stratification in cerebral cortex ( J:157301 )

• at E18.5, cortical layers are disorganized compared to in wild-type mice

abnormal brain meninges morphology ( J:157301 )

• at E14.5, the dorsal meninges are absent unlike in wild-type mice

cellular

abnormal neuron differentiation ( J:157301 )

• at E14.5, the number of intermediate progenitor cells is decreased compared to in wild-type mice

abnormal neuron proliferation ( J:157301 )

• at E14.5, neuron proliferation in the cortex is reduced compared to in wild-type mice

• neurons exhibit cell-cycle exit defect compared with wild-type cells

• however, transplantation of wild-type meninges increases proliferation while treatment with retinoic acid increases cell-cycle exit

Allelic Composition	Foxc1^hith/Foxc1^hith
Genetic Background	involves: C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxc1^hith mutation (0 available); any Foxc1 mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Eye, skull, and brain abnormalities in Foxc1^hith/Foxc1^hith mice

nervous system

abnormal radial glial cell morphology ( J:136459 )

• at E18.5, radial glia are disorganized with detached endfeet in the areas of basement membrane disruptions

radial glial endfoot detachment ( J:136459 )

• detachment of radial glial endfeet

abnormal cortical marginal zone morphology ( J:136459 )

• mice exhibit marginal zone heterotropias with dysplastic features arising between E18.5 and P7

hydrocephaly ( J:136459 )

• after P7

absent corpus callosum ( J:136459 )

abnormal hippocampus morphology ( J:136459 )

• dysgenesis

abnormal cerebral cortex morphology ( J:136459 )

• after birth, ectopic neurons are present in the cortex

• mice exhibit dyslamination

abnormal neocortex morphology ( J:136459 )

• dysgenesis

abnormal meninges morphology ( J:136459 )

• abnormalities in the meninges are most apparent at the edge of the holes in the calvarium

ectopic neuron ( J:136459 )

• after birth, ectopic neurons are present in the cortex

vision/eye

abnormal eye morphology ( J:136459 )

• the vitreal cavities are smaller than in wild-type mice

abnormal iris morphology ( J:136459 )

increased cornea thickness ( J:136459 )

• corneal thickening

absent eye anterior chamber ( J:136459 )

• absent

abnormal lens morphology ( J:136459 )

microphthalmia ( J:136459 )

craniofacial

abnormal frontal bone morphology ( J:136459 )

skeleton

abnormal frontal bone morphology ( J:136459 )

cellular

abnormal radial glial cell morphology ( J:136459 )

• at E18.5, radial glia are disorganized with detached endfeet in the areas of basement membrane disruptions

radial glial endfoot detachment ( J:136459 )

• detachment of radial glial endfeet

abnormal basement membrane morphology ( J:136459 )

• at E18.5, the basement membrane of the brain displays significant breaches at the pial surface

Allelic Composition	Foxc1^hith/Foxc1^tm1Blh
Genetic Background	involves: 129S6/SvEvTac * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxc1^hith mutation (0 available); any Foxc1 mutation (29 available)
Foxc1^tm1Blh mutation (0 available); any Foxc1 mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal neuron differentiation ( J:157301 )

• at E14.5, the number of intermediate progenitor cells is decreased compared to in wild-type mice

abnormal neuron proliferation ( J:157301 )

• at E14.5, neuron proliferation in the cortex is reduced compared to in wild-type mice

abnormal forebrain morphology ( J:157301 )

• at E12.5, dorsal forebrain lengthening is observed unlike in wild-type mice

• at E14.5, the dorsal forebrain is longer and thinner than in wild-type mice

• however, treatment with all-trans retinoic acid restores forebrain morphology

abnormal cerebral cortex morphology ( J:157301 )

• at E18.5

abnormal stratification in cerebral cortex ( J:157301 )

• at E18.5, cortical layers are disorganized compared to in wild-type mice

abnormal brain meninges morphology ( J:157301 )

• at E14.5, the lateral meninges are reduced and the dorsal meninges are absent unlike in wild-type mice

cellular

abnormal neuron differentiation ( J:157301 )

• at E14.5, the number of intermediate progenitor cells is decreased compared to in wild-type mice

abnormal neuron proliferation ( J:157301 )

• at E14.5, neuron proliferation in the cortex is reduced compared to in wild-type mice

Allelic Composition	Foxc1^hith/Foxc1^hith Tg(Rr291-lacZ)#Mekk/0
Genetic Background	involves: C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxc1^hith mutation (0 available); any Foxc1 mutation (29 available)
Tg(Rr291-lacZ)#Mekk mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal cerebral cortex morphology ( J:136795 )

• at E14.5, mice exhibit midline cortical hypertrophy

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