hematopoietic system
• mutant dendritic cells (DCs) exhibit reduced potency to indue Th17 differentiation and proliferation in vitro
• mutant mice appeared phenotypically normal, and similar immune cell numbers and proportions were observed in the lymph nodes, spleen, thymus, and bone marrow
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immune system
• mutant dendritic cells (DCs) exhibit reduced potency to indue Th17 differentiation and proliferation in vitro
• mutant mice appeared phenotypically normal, and similar immune cell numbers and proportions were observed in the lymph nodes, spleen, thymus, and bone marrow
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• in a Th17-mediated autoimmune disease model, myelin oligodendrocyte glycoprotein induced EAE, mutant mice showed a significantly reduced disease severity
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cellular
• mutant dendritic cells (DCs) exhibit reduced potency to indue Th17 differentiation and proliferation in vitro
• mutant mice appeared phenotypically normal, and similar immune cell numbers and proportions were observed in the lymph nodes, spleen, thymus, and bone marrow
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