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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tnfsf15tm1Cdon
targeted mutation 1, Chen Dong
MGI:3797013
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Tnfsf15tm1Cdon/Tnfsf15tm1Cdon B6.129-Tnfsf15tm1Cdon MGI:3797109


Genotype
MGI:3797109
hm1
Allelic
Composition
Tnfsf15tm1Cdon/Tnfsf15tm1Cdon
Genetic
Background
B6.129-Tnfsf15tm1Cdon
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfsf15tm1Cdon mutation (0 available); any Tnfsf15 mutation (21 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• mutant dendritic cells (DCs) exhibit reduced potency to indue Th17 differentiation and proliferation in vitro
• mutant mice appeared phenotypically normal, and similar immune cell numbers and proportions were observed in the lymph nodes, spleen, thymus, and bone marrow

immune system
• mutant dendritic cells (DCs) exhibit reduced potency to indue Th17 differentiation and proliferation in vitro
• mutant mice appeared phenotypically normal, and similar immune cell numbers and proportions were observed in the lymph nodes, spleen, thymus, and bone marrow
• in a Th17-mediated autoimmune disease model, myelin oligodendrocyte glycoprotein induced EAE, mutant mice showed a significantly reduced disease severity

cellular
• mutant dendritic cells (DCs) exhibit reduced potency to indue Th17 differentiation and proliferation in vitro
• mutant mice appeared phenotypically normal, and similar immune cell numbers and proportions were observed in the lymph nodes, spleen, thymus, and bone marrow





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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory