Phenotypes associated with this allele

• Allele Symbol: Mgam^tm1Lex
• Allele Name: targeted mutation 1, Lexicon Genetics
• Allele ID: MGI:3797062
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mgam^tm1Lex/Mgam^tm1Lex	129/Sv-Mgam^tm1Lex	MGI:3806715

Genotype
MGI:3806715

hm1

• Allelic Composition: Mgam^tm1Lex/Mgam^tm1Lex
• Genetic Background: 129/Sv-Mgam^tm1Lex

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased circulating insulin level ( J:146501 )

• in mice fed a diet high in corn starch and in mice infused with ¹³C corn alpha-limit-dextran compared to wild-type controls

decreased glycogen catabolism rate ( J:146501 )

• M+6 isotopomer-specific blood glucose levels are 40% lower following infusion of ¹³C corn alpha-limit-dextran compared to wild-type controls

abnormal metabolism ( J:136590 )

• decrease in starch digestion as measured by ¹³CO2 concentrations in the breath following ¹³C corn alpha-limit-dextran bolus feeding

abnormal enzyme/coenzyme activity ( J:136590 , J:146501 )

• alpha-glucosidase activity is reduced 50% in the jejunum compared to in wild-type mice (J:136590)

• in the jejunum, maltase, maltodextrinase and amylase activities are reduced while sucrase and lactase activity are increased compared to in wild-type mice (J:136590)

• in the ileum, maltase and amylase activity are decreased while sucrase and lactase activities are increased compared to in wild-type mice (J:136590)

• however, rates of alpha-glucogenesis with isomaltase as a substrate are normal (J:136590)

• lower jejunal alpha-glucosidase activity after 30 h of food deprivation and in mice fed a diet high in corn starch or in sucrose compared to wild-type controls (J:146501)

• lower illeal alpha-glucosidase activity in mice fed a diet high in corn starch or in sucrose compared to wild-type controls (J:146501)

• illeal sucrase activity is higher in mice after 30 h of food deprivation and in mice fed a diet high in sucrose compared to wild-type controls (J:146501)