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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Epha6tm1Lex
targeted mutation 1, Lexicon Genetics
MGI:3797071
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Epha6tm1Lex/Epha6tm1Lex involves: 129S5/SvEvBrd * C57BL/6J MGI:3806691


Genotype
MGI:3806691
hm1
Allelic
Composition
Epha6tm1Lex/Epha6tm1Lex
Genetic
Background
involves: 129S5/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Epha6tm1Lex mutation (2 available); any Epha6 mutation (59 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• freezing is decreased relative to wild-type controls when placed in the training context 24h after training
• while freezing increased across trials, freezing to tone was decreased relative to wild-type controls
• however, no differences are detected in motor activity, auditory reactivity or pain responsiveness
• on the first day of reversal training homozygotes took longer to learn the new platform location compared to wild-type controls
• while escape latency decreases across trials in a Morris water maze, performance is impaired relative to wild-type controls
• however, no difference is detected in swim speed or distance traveled





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory