Analysis Tools
hematopoietic system
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• mice exhibit enlargement of the spleen due to infiltration of the red pulp with highly proliferative cells
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• the number of committed erythroid progenitors in the bone marrow and spleen is increased while myeloid cell numbers are decreased resulting in a decrease in the myeloid to erythroid ratio
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• peripheral blood defects are less severe than in the bone marrow
• mice exhibit a decrease in the number of enucleated Ter119+ erythroid cells and these cells do not accumulate as in wild-type mice
• red blood cell size is abnormal
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• despite the increase in erythroid progenitor cells, erythroid development is impaired and erythropoiesis is ineffective leading to a decrease in mature erythroid cells
• following transplantation into wild-type mice, early progenitor cells expand but exhibit impaired maturation
• unlike in Ccne1tm1Jro homozygotes, immature erythroid cells in the bone marrow accumulate and exhibit impaired differentiation, dysplasia and increased apoptosis
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• the number of myeloid cells in the bone marrow is decreased compared to in wild-type mice
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• mice exhibit infiltration of the red pulp with highly proliferative cells
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reproductive system
| N |
• despite in increase in mammary epithelia, mammary gland morphology during pregnancy is normal
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digestive/alimentary system
| N |
• despite in increase in gut epithelia, adult colonic morphology is normal
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• gut epithelium exhibits increased proliferation and apoptosis compared to in wild-type mice
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skeleton
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• unlike in Ccne1tm1Jro homozygotes, the bone marrow is composed of a large expansion of immature and abnormally proliferating erythroid cells with impaired differentiation, dysplasia and increased apoptosis
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immune system
| N |
• despite increased proliferation in the spleen, the thymus is normal
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• mice exhibit enlargement of the spleen due to infiltration of the red pulp with highly proliferative cells
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• the number of myeloid cells in the bone marrow is decreased compared to in wild-type mice
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• mice exhibit infiltration of the red pulp with highly proliferative cells
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endocrine/exocrine glands
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• mammary epithelium exhibits increased proliferation compared to in wild-type mice
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• unlike in wild-type mice, intact acinar structures persist during involution and the size of terminal mammary duct lobules is increased
• however, prolactin and estradiol levels are normal during involution
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• mammary epithelium exhibits increased apoptosis compared to in wild-type mice
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integument
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• mammary epithelium exhibits increased proliferation compared to in wild-type mice
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• unlike in wild-type mice, intact acinar structures persist during involution and the size of terminal mammary duct lobules is increased
• however, prolactin and estradiol levels are normal during involution
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• mammary epithelium exhibits increased apoptosis compared to in wild-type mice
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cellular
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• mammary epithelium exhibits increased proliferation compared to in wild-type mice
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growth/size/body
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• mice exhibit enlargement of the spleen due to infiltration of the red pulp with highly proliferative cells
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