Phenotypes associated with this allele

• Allele Symbol: Sync^tm1Chen
• Allele Name: targeted mutation 1, Ju CHen
• Allele ID: MGI:3797113
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sync^tm1Chen/Sync^tm1Chen	involves: 129X1/SvJ * Black Swiss	MGI:3805933

Genotype
MGI:3805933

hm1

• Allelic Composition: Sync^tm1Chen/Sync^tm1Chen
• Genetic Background: involves: 129X1/SvJ * Black Swiss

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:136645 )

N • cardiac muscle shows no morphological abnormalities; no fibrosis is detected

N • cardiac function is normal in mutants, and response to hypertrophic stimuli is similar to wild-type

muscle

muscle phenotype ( J:136645 )

N • skeletal muscle shows no morphological abnormalities; no centralized nuclei, increased fiber size variability, abnormal fiber shape or altered fiber density are observed

N • no fibrosis is detected

abnormal muscle physiology ( J:136645 )

• 10-week old mice display 25% lower whole muscle stress production compared to wild-type but show same susceptibility to injury induced by cyclic eccentric contractions in 5th toe muscle of EDL muscle

• passive tensile stress in whole fifth toe muscles from EDL subjected to 10% stretch is normal; exercise capacity in treadmill tests to exhaustion is similar to wild-type