Phenotypes associated with this allele

• Allele Symbol: Ccl25^tm1.1Mal
• Allele Name: targeted mutation 1.1, Bernard Malissen
• Allele ID: MGI:3797365
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ccl25^tm1.1Mal/Ccl25^tm1.1Mal	B6.129S2-Ccl25^tm1.1Mal	MGI:3799631
cx2	Ccl25^tm1.1Mal/Ccl25^tm1.1Mal Tnf^tm2Gkl/Tnf^+	involves: 129S/SvEv * 129S2/SvPas * C57BL/6	MGI:3799633

Genotype
MGI:3799631

hm1

• Allelic Composition: Ccl25^tm1.1Mal/Ccl25^tm1.1Mal
• Genetic Background: B6.129S2-Ccl25^tm1.1Mal

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal T cell subpopulation ratio ( J:136944 )

• in the lamina propria of the intestine the proportion of CD8+ T cells is reduced and there is a relative increase in CD4+ T cells and B cells

abnormal gamma-delta T cell number ( J:136944 )

• increase in the relative percentage of gamma-delta T cells in the mesenteric lymph node

decreased gamma-delta intraepithelial T cell number ( J:136944 )

• decrease in the total number of intraepithelial lymphocytes primarily apparently due to a reduction in the number of gamma-delta intraepithelial lymphocytes

• only account for 20-30% of the total intraepeithelial lymphocyte T cell population

abnormal mesenteric lymph node morphology ( J:136944 )

• increase in the relative percentage of gamma-delta T cells

hematopoietic system

abnormal T cell subpopulation ratio ( J:136944 )

• in the lamina propria of the intestine the proportion of CD8+ T cells is reduced and there is a relative increase in CD4+ T cells and B cells

abnormal gamma-delta T cell number ( J:136944 )

• increase in the relative percentage of gamma-delta T cells in the mesenteric lymph node

decreased gamma-delta intraepithelial T cell number ( J:136944 )

• decrease in the total number of intraepithelial lymphocytes primarily apparently due to a reduction in the number of gamma-delta intraepithelial lymphocytes

• only account for 20-30% of the total intraepeithelial lymphocyte T cell population

Genotype
MGI:3799633

cx2

• Allelic Composition: Ccl25^tm1.1Mal/Ccl25^tm1.1Mal; Tnf^tm2Gkl/Tnf⁺
• Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6

immune system

intestinal inflammation ( J:136667 )

• develop inflammatory bowl disease with similar onset, progression, and severity as in littermates heterozygous for both alleles

• elevated acute and chronic inflammatory indices similar to littermates heterozygous for both alleles

abnormal T cell subpopulation ratio ( J:136667 )

• decrease in the CD8alpha alpha to CD8alpha beta ratio similar to that in mice heterozygous for Tnf^tm2Gkl alone

decreased gamma-delta intraepithelial T cell number ( J:136667 )

• more pronounced decrease in this subset early in the inflammatory disease process compared to mice heterozygous for Tnf^tm2Gkl alone

abnormal alpha-beta intraepithelial T cell morphology ( J:136667 )

• decrease in TCRalpha beta CD8alpha alpha and TCRalpha beta CD8alpha alpha CD4 numbers similar to mice heterozygous for Tnf^tm2Gkl alone

digestive/alimentary system

intestinal inflammation ( J:136667 )

• develop inflammatory bowl disease with similar onset, progression, and severity as in littermates heterozygous for both alleles

• elevated acute and chronic inflammatory indices similar to littermates heterozygous for both alleles

hematopoietic system

abnormal T cell subpopulation ratio ( J:136667 )

• decrease in the CD8alpha alpha to CD8alpha beta ratio similar to that in mice heterozygous for Tnf^tm2Gkl alone

decreased gamma-delta intraepithelial T cell number ( J:136667 )

• more pronounced decrease in this subset early in the inflammatory disease process compared to mice heterozygous for Tnf^tm2Gkl alone

abnormal alpha-beta intraepithelial T cell morphology ( J:136667 )

• decrease in TCRalpha beta CD8alpha alpha and TCRalpha beta CD8alpha alpha CD4 numbers similar to mice heterozygous for Tnf^tm2Gkl alone