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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pdss2tm1Dalg
targeted mutation 1, David L Gasser
MGI:3797368
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Pdss2tm1Dalg/Pdss2tm1Dalg involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3805705
cn2
 		Pdss2tm1Dalg/Pdss2tm1Dalg
Tg(NPHS2-cre)295Lbh/? 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3805706
cn3
 		Pdss2tm1Dalg/Pdss2tm1Dalg
Hprt1tm1(Pck1-cre)Vhh/? 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3805707
cn4
 		Pdss2tm1Dalg/Pdss2tm1Dalg
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3805708


Genotype
MGI:3805705
hm1
Allelic
Composition		 Pdss2tm1Dalg/Pdss2tm1Dalg
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdss2tm1Dalg mutation (0 available); any Pdss2 mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
renal/urinary system phenotype ( J:136670 )
N
• kidney ultrastructure normal
• no evidence of nephritis

homeostasis/metabolism
homeostasis/metabolism phenotype ( J:136670 )
N
• normal serum albumin levels




Genotype
MGI:3805706
cn2
Allelic
Composition		 Pdss2tm1Dalg/Pdss2tm1Dalg
Tg(NPHS2-cre)295Lbh/?
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdss2tm1Dalg mutation (0 available); any Pdss2 mutation (31 available)
Tg(NPHS2-cre)295Lbh mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
tubulointerstitial nephritis ( J:136670 )
• histological evidence of nephritis
abnormal renal tubule morphology ( J:136670 )
• extensive interstitial infiltration

homeostasis/metabolism
increased circulating cholesterol level ( J:136670 )
• elevated plasma cholesterol

immune system
tubulointerstitial nephritis ( J:136670 )
• histological evidence of nephritis




Genotype
MGI:3805707
cn3
Allelic
Composition		 Pdss2tm1Dalg/Pdss2tm1Dalg
Hprt1tm1(Pck1-cre)Vhh/?
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hprt1tm1(Pck1-cre)Vhh mutation (0 available); any Hprt1 mutation (1279 available)
Pdss2tm1Dalg mutation (0 available); any Pdss2 mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
renal/urinary system phenotype ( J:136670 )
N
• kidney ultrastructure normal
• no evidence of nephritis

homeostasis/metabolism
homeostasis/metabolism phenotype ( J:136670 )
N
• normal urine albumin levels




Genotype
MGI:3805708
cn4
Allelic
Composition		 Pdss2tm1Dalg/Pdss2tm1Dalg
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdss2tm1Dalg mutation (0 available); any Pdss2 mutation (31 available)
Speer6-ps1Tg(Alb-cre)21Mgn mutation (6 available); any Speer6-ps1 mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal mitophagy ( J:136670 )
• increased autophagy of mitochondria
abnormal circulating cholesterol level ( J:136670 )
• elevated plasma cholesterol
abnormal energy homeostasis ( J:136670 )
• many biochemical pathways involved in energy production are upregulated

cellular
abnormal mitophagy ( J:136670 )
• increased autophagy of mitochondria
abnormal aerobic respiration ( J:136670 )
• impaired mitochondrial respiration
abnormal respiratory electron transport chain ( J:136670 )
• significant decrease in complex I and complex II-dependent respiratory chain capacity in liver




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory