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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Thap11tm1Tpz
targeted mutation 1, Thomas P Zwaka
MGI:3797582
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Thap11tm1Tpz/Thap11tm1Tpz involves: 129S1/Sv * 129X1/SvJ MGI:3799319
cn2
 		Thap11tm1Tpz/Thap11tm1Tpz
E2f1Tg(Wnt1-cre)2Sor/E2f1+ 		involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C3H * C57BL/6 MGI:6861816
cn3
 		Thap11tm1Tpz/Thap11em1Poche
E2f1Tg(Wnt1-cre)2Sor/E2f1+ 		involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J MGI:7310234
cn4
 		Thap11tm1Tpz/Thap11tm1Tpz
Tg(Prrx1-cre)1Cjt/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J MGI:6861814


Genotype
MGI:3799319
cn1
Allelic
Composition		 Thap11tm1Tpz/Thap11tm1Tpz
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Thap11tm1Tpz mutation (0 available); any Thap11 mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal cell physiology ( J:136306 )
• cre-transfected ES cells show an apparent high rate of apoptosis and no homozygous recombined sub-clones are found
• however, cre-transduced MEFs from E14.5 embryos show nearly 100% recombination




Genotype
MGI:6861816
cn2
Allelic
Composition		 Thap11tm1Tpz/Thap11tm1Tpz
E2f1Tg(Wnt1-cre)2Sor/E2f1+
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
E2f1Tg(Wnt1-cre)2Sor mutation (2 available); any E2f1 mutation (28 available)
Thap11tm1Tpz mutation (0 available); any Thap11 mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
abnormal craniofacial development ( J:317822 )
• mice show almost complete agenesis of the neural crest-derived craniofacial skeleton




Genotype
MGI:7310234
cn3
Allelic
Composition		 Thap11tm1Tpz/Thap11em1Poche
E2f1Tg(Wnt1-cre)2Sor/E2f1+
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
E2f1Tg(Wnt1-cre)2Sor mutation (2 available); any E2f1 mutation (28 available)
Thap11em1Poche mutation (0 available); any Thap11 mutation (10 available)
Thap11tm1Tpz mutation (0 available); any Thap11 mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
belly spot ( J:317822 )
• 2 out of 5 mice exhibit white belly spots
decreased digit pigmentation ( J:317822 )
• hypopigmented paws

limbs/digits/tail
decreased digit pigmentation ( J:317822 )
• hypopigmented paws

pigmentation
belly spot ( J:317822 )
• 2 out of 5 mice exhibit white belly spots
decreased digit pigmentation ( J:317822 )
• hypopigmented paws




Genotype
MGI:6861814
cn4
Allelic
Composition		 Thap11tm1Tpz/Thap11tm1Tpz
Tg(Prrx1-cre)1Cjt/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Prrx1-cre)1Cjt mutation (2 available)
Thap11tm1Tpz mutation (0 available); any Thap11 mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
abnormal craniofacial development ( J:317822 )
• mice show a dramatic loss of mesoderm-derived bones in the skull




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory