Phenotypes associated with this allele

• Allele Symbol: Thap11^tm1.1Tpz
• Allele Name: targeted mutation 1.1, Thomas P Zwaka
• Allele ID: MGI:3797583
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Thap11^tm1.1Tpz/Thap11^tm1.1Tpz	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3799320

Genotype
MGI:3799320

hm1

• Allelic Composition: Thap11^tm1.1Tpz/Thap11^tm1.1Tpz
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:136306 )

• the expected percentage of blastocyst stage embryos are found but by E7.5 no viable homozygous embryos are present

embryo

absent inner cell mass proliferation ( J:136306 )

• in all but one cultured embryo the inner cell mass failed to proliferate and in the single exception produced only a residual mass

cellular

abnormal cell physiology ( J:136306 )

• despite repeated attempts no ES cell lines could be generated

absent inner cell mass proliferation ( J:136306 )

• in all but one cultured embryo the inner cell mass failed to proliferate and in the single exception produced only a residual mass