Phenotypes associated with this allele

• Allele Symbol: Ankrd11^Yod
• Allele Name: yoda
• Allele ID: MGI:3797584
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ankrd11^Yod/Ankrd11^Yod	involves: BALB/cAnNCrl * C3H/HeH	MGI:3797613
ht2	Ankrd11^Yod/Ankrd11^+	involves: BALB/cAnNCrl * C3H/HeH	MGI:3797614

Genotype
MGI:3797613

hm1

• Allelic Composition: Ankrd11^Yod/Ankrd11^Yod
• Genetic Background: involves: BALB/cAnNCrl * C3H/HeH

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:136455 )

• mice die at E9.5

embryo

failure of initiation of embryo turning ( J:136455 )

decreased embryo size ( J:136455 )

growth/size/body

decreased embryo size ( J:136455 )

Genotype
MGI:3797614

ht2

• Allelic Composition: Ankrd11^Yod/Ankrd11⁺
• Genetic Background: involves: BALB/cAnNCrl * C3H/HeH

skeleton

abnormal craniofacial bone morphology ( J:136455 )

abnormal metopic suture morphology ( J:136455 )

• incomplete closure

abnormal frontonasal suture morphology ( J:136455 )

• mice exhibit decreased interdigitation of the frontonasal suture compared to in wild-type mice

increased cranium width ( J:136455 )

short frontal bone ( J:136455 )

enlarged parietal bone ( J:136455 )

• increased in length

abnormal nasal bone morphology ( J:136455 )

• the nasal bone morphology is altered such that the skull has a domed shape

short nasal bone ( J:136455 )

domed cranium ( J:136455 )

kyphosis ( J:136455 )

• in 80% of female mice at 20 to 22 months of age

abnormal bone structure ( J:136455 )

• the periosteal perimeter is decreased in female but not male mice compared to wild-type mice

• the enodosteal perimeter and medullary areas are decreased in male and female mice compared to wild-type mice

decreased osteoclast cell number ( J:136455 )

• in female but not male mice

decreased bone mineral density of femur ( J:136455 )

• at 3 months of age, bone mineral density is decreased 5.5% in the femora compared to in wild-type femora

• at 7 months of age, bone mineral density is decreased 27% in the femora compared to in wild-type femora

decreased compact bone area ( J:136455 )

• cortical bone area is decreased in female but not male mice compared to wild-type mice

decreased bone mass ( J:136455 )

• mice exhibit loss of bone mass that is more severe in female mice

• however, cancellous bone mass is normal

growth/size/body

abnormal nasal bone morphology ( J:136455 )

• the nasal bone morphology is altered such that the skull has a domed shape

short nasal bone ( J:136455 )

broad face ( J:136455 )

• mice exhibit shorter and wider faces than wild-type mice

short face ( J:136455 )

• mice exhibit shorter and wider faces than wild-type mice

decreased body weight ( J:136455 )

• at weaning and persisting through the rest of their lives

• however, lean and fat mass are normal

decreased body length ( J:136455 )

• at weaning mice are shorter in length than wild-type mice and at 6 months mice are 9% shorter in length than wild-type mice

homeostasis/metabolism

decreased circulating leptin level ( J:136455 )

immune system

decreased osteoclast cell number ( J:136455 )

• in female but not male mice

craniofacial

abnormal craniofacial bone morphology ( J:136455 )

abnormal metopic suture morphology ( J:136455 )

• incomplete closure

abnormal frontonasal suture morphology ( J:136455 )

• mice exhibit decreased interdigitation of the frontonasal suture compared to in wild-type mice

increased cranium width ( J:136455 )

short frontal bone ( J:136455 )

enlarged parietal bone ( J:136455 )

• increased in length

abnormal nasal bone morphology ( J:136455 )

• the nasal bone morphology is altered such that the skull has a domed shape

short nasal bone ( J:136455 )

domed cranium ( J:136455 )

broad face ( J:136455 )

• mice exhibit shorter and wider faces than wild-type mice

short face ( J:136455 )

• mice exhibit shorter and wider faces than wild-type mice

hematopoietic system

decreased osteoclast cell number ( J:136455 )

• in female but not male mice

respiratory system

abnormal nasal bone morphology ( J:136455 )

• the nasal bone morphology is altered such that the skull has a domed shape

short nasal bone ( J:136455 )