cardiovascular system
• larger caliber vessels and prominent balloon-like spots are seen
• Background Sensitivity: vascular abnormalities are less prominent in mice on a C57BL/6 background compared to mice on an outbred CD-1 background
• however, the retinal vasculature appears normal
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• aortic explants show increased spontaneous microvessel outgrowth which can be inhibited with the addition of recombinant TIMP3 or a VEGFR2 inhibitor
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vision/eye
• larger caliber vessels and prominent balloon-like spots are seen
• Background Sensitivity: vascular abnormalities are less prominent in mice on a C57BL/6 background compared to mice on an outbred CD-1 background
• however, the retinal vasculature appears normal
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