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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Timp3tm1Hest
targeted mutation 1, Heidi Stohr
MGI:3797605
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Timp3tm1Hest/Timp3tm1Hest either: B6.129S1-Timp3tm1Hest or (involves: 129S1/Sv * CD-1) MGI:3799161


Genotype
MGI:3799161
hm1
Allelic
Composition
Timp3tm1Hest/Timp3tm1Hest
Genetic
Background
either: B6.129S1-Timp3tm1Hest or (involves: 129S1/Sv * CD-1)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Timp3tm1Hest mutation (1 available); any Timp3 mutation (19 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• larger caliber vessels and prominent balloon-like spots are seen
• Background Sensitivity: vascular abnormalities are less prominent in mice on a C57BL/6 background compared to mice on an outbred CD-1 background
• however, the retinal vasculature appears normal
• aortic explants show increased spontaneous microvessel outgrowth which can be inhibited with the addition of recombinant TIMP3 or a VEGFR2 inhibitor

vision/eye
• larger caliber vessels and prominent balloon-like spots are seen
• Background Sensitivity: vascular abnormalities are less prominent in mice on a C57BL/6 background compared to mice on an outbred CD-1 background
• however, the retinal vasculature appears normal





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory