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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pcdhatm3Tyag
targeted mutation 3, Takeshi Yagi
MGI:3797610
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Pcdhatm3Tyag/Pcdhatm3Tyag B6.Cg-Pcdhatm3Tyag MGI:4356106
hm2
 		Pcdhatm3Tyag/Pcdhatm3Tyag involves: C57BL/6 MGI:3799112
cx3
 		Or8a1tm25Mom/?
Or8a1btm6Mom/?
Pcdhatm3Tyag/Pcdhatm3Tyag 		involves: 129P2/OlaHsd * C57BL/6 MGI:3799116
cx4
 		Or10j5tm1Mom/?
Pcdhatm3Tyag/Pcdhatm3Tyag 		involves: C57BL/6 MGI:3799113
cx5
 		Or8a1tm25Mom/?
Pcdhatm3Tyag/Pcdhatm3Tyag 		involves: C57BL/6 MGI:3799114


Genotype
MGI:4356106
hm1
Allelic
Composition		 Pcdhatm3Tyag/Pcdhatm3Tyag
Genetic
Background		 B6.Cg-Pcdhatm3Tyag
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pcdhatm3Tyag mutation (8 available); any Pcdha mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:151979 )
N
• cortical barrel fields are structurally normal
abnormal substantia nigra morphology ( J:151979 )
• the density of serotonergic fibers is increased in the peripheral region and decreased in the central region compared to in wild-type mice
abnormal globus pallidus morphology ( J:151979 )
• the density of serotonergic fibers is increased in the peripheral region and decreased in the central region compared to in wild-type mice
abnormal dorsal striatum morphology ( J:151979 )
• the density of serotonergic fibers is decreased in the caudate putamen compared to in wild-type mice
abnormal thalamus morphology ( J:151979 )
• serotonergic fibers accumulate around the dorsal lateral geniculate nucleus and the medial geniculate nucleus but are sparse in the central regions of these nuclei unlike in wild-type mice
abnormal lateral geniculate nucleus morphology ( J:151979 )
• serotonergic fibers accumulate around the dorsal lateral geniculate nucleus and the medial geniculate nucleus but are sparse in the central regions of these nuclei unlike in wild-type mice
abnormal medial geniculate nucleus morphology ( J:151979 )
• serotonergic fibers accumulate around the dorsal lateral geniculate nucleus and the medial geniculate nucleus but are sparse in the central regions of these nuclei unlike in wild-type mice
abnormal cingulate gyrus morphology ( J:151979 )
• mice exhibit decreased density of serotonergic fibers in the cingulate cortex compared with wild-type mice
abnormal entorhinal cortex morphology ( J:151979 )
• the density of serotonergic fibers are greater in the entorhinal cortex compared to in wild-type mice
abnormal hippocampus morphology ( J:151979 )
• serotonergic fibers are increased in the lacunosum-moleculare (184%) and the stratum radiatum (134%) of the CA1 region compared to in wild-type mice
• serotonergic fibers are decreased in the stratum oriens (44%) and dentage gyrus (21%) compared to in wild-type mice
abnormal dentate gyrus morphology ( J:151979 )
• serotonergic fibers are decreased 21% in the dentage gyrus compared to in wild-type mice
abnormal primary motor cortex morphology ( J:151979 )
• in the rostral part of the primary motor cortex, serotonergic fibers more densely innervated layer I and short, clumped fibers are frequently observed in layer II/III of only the most rostral part of the primary motor cortex compared to in wild-type mice
abnormal olfactory bulb morphology ( J:151979 )
• mice exhibit fewer serotonergic fibers in the layers encompassed by and including the external and internal plexiform layers compared to in wild-type mice
• mice exhibit more serotonergic fibers in the granule cell layer compared to in wild-type mice
abnormal serotonergic neuron morphology ( J:151979 )
• mice exhibit abnormal serotonergic fibers in the cerebral cortex, hippocampus, basal ganglia, and thalamus compared to in wild-type mice

behavior/neurological
increased grooming behavior ( J:151979 )
• resulting in lesions

growth/size/body
decreased body weight ( J:151979 )
• at 72 to 84 weeks

homeostasis/metabolism
increased serotonin level ( J:151979 )
• at 10 weeks, the level of serotonin is higher in the hippocampus compared to in wild-type mice

integument
skin lesions ( J:151979 )
• by 36 weeks, mice develop lesions on their head, neck, and snout unlike in wild-type mice




Genotype
MGI:3799112
hm2
Allelic
Composition		 Pcdhatm3Tyag/Pcdhatm3Tyag
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pcdhatm3Tyag mutation (8 available); any Pcdha mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal olfactory bulb morphology ( J:136920 )
• more, small glomeruli are present




Genotype
MGI:3799116
cx3
Allelic
Composition		 Or8a1tm25Mom/?
Or8a1btm6Mom/?
Pcdhatm3Tyag/Pcdhatm3Tyag
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Or8a1btm6Mom mutation (4 available); any Or8a1b mutation (35 available)
Or8a1tm25Mom mutation (6 available); any Or8a1 mutation (69 available)
Pcdhatm3Tyag mutation (8 available); any Pcdha mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal olfactory bulb morphology ( J:136920 )
• labeled axons form multiple glomeruli but none of the olfactory sensory neurons express both GFP and lacZ indicating olfactory receptor gene choice is not perturbed




Genotype
MGI:3799113
cx4
Allelic
Composition		 Or10j5tm1Mom/?
Pcdhatm3Tyag/Pcdhatm3Tyag
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Or10j5tm1Mom mutation (5 available); any Or10j5 mutation (46 available)
Pcdhatm3Tyag mutation (8 available); any Pcdha mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal olfactory bulb morphology ( J:136920 )
• more, small glomeruli are present
abnormal olfactory bulb development ( J:136920 )
• at P7, coalescence of MOR23 axons into glomeruli is disturbed with the average number of labeled glomeruli increased to 3.3 and 2.2 in the lateral and medial half-bulbs, respectively compared to 1.0 and 1.1 in wild-type controls
• several of these glomeruli appear smaller than in controls
• however, almost all glomeruli appear homogeneous




Genotype
MGI:3799114
cx5
Allelic
Composition		 Or8a1tm25Mom/?
Pcdhatm3Tyag/Pcdhatm3Tyag
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Or8a1tm25Mom mutation (6 available); any Or8a1 mutation (69 available)
Pcdhatm3Tyag mutation (8 available); any Pcdha mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal olfactory bulb morphology ( J:136920 )
• more, small glomeruli are present
abnormal olfactory bulb development ( J:136920 )
• at P7, coalescence of M71 axons into glomeruli is disturbed with the average number of labeled glomeruli increased to 5.4 and 3.0 in the lateral and medial half-bulbs, respectively compared to 1.0 and 1.3 in heterozygous and wild-type controls
• several of these glomeruli appear smaller than in controls
• at P30, almost all mice still show more than 3 glomeruli per half-bulb and fewer glomeruli appear homogeneous
• at P60 multiple small glomeruli persist




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory