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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Unc93b1tm1(KOMP)Vlcg
targeted mutation 1, Velocigene
MGI:3797728
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Unc93b1tm1(KOMP)Vlcg/Unc93b1tm1(KOMP)Vlcg involves: C57BL/6NTac MGI:5581824


Genotype
MGI:5581824
hm1
Allelic
Composition		 Unc93b1tm1(KOMP)Vlcg/Unc93b1tm1(KOMP)Vlcg
Genetic
Background		 involves: C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Unc93b1tm1(KOMP)Vlcg mutation (1 available); any Unc93b1 mutation (39 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal dendritic cell morphology ( J:211069 )
• disrupted TLR5-localization on plasma membrane of bone marrow-derived dendritic cells
decreased circulating interleukin-12b level ( J:211069 )
• no increase in serum levels of interleukin-12p40 in splenic dendritic cells following intraperitoneal injection of flagellin
decreased circulating interleukin-6 level ( J:211069 )
• no increase in serum levels of interleukin-6 in splenic dendritic cells following intraperitoneal injection of flagellin
abnormal tumor necrosis factor level ( J:211069 )
• bone marrow-derived dendritic cells do not secrete TNF-alpha upon flagellin stimulation even with overexpression toll-like receptor 5
abnormal dendritic cell physiology ( J:211069 )
• bone marrow-derived dendritic cells hardly express TLR5 nor undergo NFKBIB phosphorlyation upon flagellin stimulation
abnormal dendritic cell antigen presentation ( J:211069 )
• splenic-derived dendritic cells do not secrete CD40 or CD86 upon flagellin stimulation in vitro and in vivo

hematopoietic system
abnormal dendritic cell morphology ( J:211069 )
• disrupted TLR5-localization on plasma membrane of bone marrow-derived dendritic cells

homeostasis/metabolism
decreased circulating interleukin-12b level ( J:211069 )
• no increase in serum levels of interleukin-12p40 in splenic dendritic cells following intraperitoneal injection of flagellin
decreased circulating interleukin-6 level ( J:211069 )
• no increase in serum levels of interleukin-6 in splenic dendritic cells following intraperitoneal injection of flagellin
abnormal tumor necrosis factor level ( J:211069 )
• bone marrow-derived dendritic cells do not secrete TNF-alpha upon flagellin stimulation even with overexpression toll-like receptor 5




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory