All Phenotypes Isl1<tm2Gan> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Isl1^tm2Gan
targeted mutation 2, Lin Gan
MGI:3797783

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Isl1^tm2Gan/Isl1^tm2Gan Tg(Six3-cre)69Frty/?	involves: 129S6/SvEvTac * C57BL/6 * DBA/2	MGI:3797795
cn2	Isl1^tm2Gan/Isl1^tm2Gan Pou4f2^tm1(ALPP)Whk/Pou4f2^tm2Whk Tg(Six3-cre)69Frty/?	involves: 129S6/SvEvTac * C57BL/6 * DBA/2	MGI:3797796
cn3	Isl1^tm1Gan/Isl1^tm2Gan Pou4f2^tm1(ALPP)Whk/Pou4f2^tm2Whk Tg(Six3-cre)69Frty/?	involves: 129S6/SvEvTac * C57BL/6 * DBA/2	MGI:3797797
cn4	Isl1^tm1Gan/Isl1^tm2Gan Tg(Six3-cre)69Frty/?	involves: 129S6/SvEvTac * C57BL/6 * DBA/2	MGI:3797794

Allelic Composition	Isl1^tm2Gan/Isl1^tm2Gan Tg(Six3-cre)69Frty/?
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Isl1^tm2Gan mutation (0 available); any Isl1 mutation (36 available)
Tg(Six3-cre)69Frty mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal optic nerve innervation ( J:134978 )

• retinal ganglion axons fail to reach the midline at E13.5

• At E15.5, the axons in the optic nerve are less fasciculated and appear to be grouped into two bundles

• in addition, a substantial portion of retinal ganglion cells fail to send out axons or their axons do not exit the optic cup

retina ganglion cell degeneration ( J:134978 )

• retinal ganglion cells expressing Pou4f2 are lost from the center of the retina to the periphery starting at E17.5

• there is a corresponding increase in the number of apoptotic cells in the ganglion cell layer starting at E16.5 and peaking at E17.5

• adult mice only have about a third the number of retinal ganglion cells as do the controls

optic nerve hypoplasia ( J:134978 )

• mice have much thinner optic nerves, optic chiasms and optic tracts

nervous system

abnormal optic tract morphology ( J:134978 )

• mice have much thinner optic nerves, optic chiasms and optic tracts

abnormal optic nerve innervation ( J:134978 )

• retinal ganglion axons fail to reach the midline at E13.5

• At E15.5, the axons in the optic nerve are less fasciculated and appear to be grouped into two bundles

• in addition, a substantial portion of retinal ganglion cells fail to send out axons or their axons do not exit the optic cup

retina ganglion cell degeneration ( J:134978 )

• retinal ganglion cells expressing Pou4f2 are lost from the center of the retina to the periphery starting at E17.5

• there is a corresponding increase in the number of apoptotic cells in the ganglion cell layer starting at E16.5 and peaking at E17.5

• adult mice only have about a third the number of retinal ganglion cells as do the controls

optic nerve hypoplasia ( J:134978 )

• mice have much thinner optic nerves, optic chiasms and optic tracts

Allelic Composition	Isl1^tm2Gan/Isl1^tm2Gan Pou4f2^tm1(ALPP)Whk/Pou4f2^tm2Whk Tg(Six3-cre)69Frty/?
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Isl1^tm2Gan mutation (0 available); any Isl1 mutation (36 available)
Pou4f2^tm1(ALPP)Whk mutation (0 available); any Pou4f2 mutation (7 available)
Pou4f2^tm2Whk mutation (0 available); any Pou4f2 mutation (7 available)
Tg(Six3-cre)69Frty mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

retina ganglion cell degeneration ( J:134978 )

• retinal ganglion cells expressing Pou4f1 are severely reduced in adult retina

• adult mice only have about 5% the number of retinal ganglion cells as do the controls

• genesis of RGCs are not affected as they are present in E13.5 embryos

optic nerve hypoplasia ( J:134978 )

• the optic nerve is barely detectable in adults with only a very limited number of axon bundles present

nervous system

retina ganglion cell degeneration ( J:134978 )

• retinal ganglion cells expressing Pou4f1 are severely reduced in adult retina

• adult mice only have about 5% the number of retinal ganglion cells as do the controls

• genesis of RGCs are not affected as they are present in E13.5 embryos

optic nerve hypoplasia ( J:134978 )

• the optic nerve is barely detectable in adults with only a very limited number of axon bundles present

Allelic Composition	Isl1^tm1Gan/Isl1^tm2Gan Pou4f2^tm1(ALPP)Whk/Pou4f2^tm2Whk Tg(Six3-cre)69Frty/?
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Isl1^tm1Gan mutation (0 available); any Isl1 mutation (36 available)
Isl1^tm2Gan mutation (0 available); any Isl1 mutation (36 available)
Pou4f2^tm1(ALPP)Whk mutation (0 available); any Pou4f2 mutation (7 available)
Pou4f2^tm2Whk mutation (0 available); any Pou4f2 mutation (7 available)
Tg(Six3-cre)69Frty mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

retina ganglion cell degeneration ( J:134978 )

• retinal ganglion cells expressing Pou4f1 are severely reduced in adult retina

• adult mice only have about 5% the number of retinal ganglion cells as do the controls

• genesis of RGCs are not affected as they are present in E13.5 embryos

optic nerve hypoplasia ( J:134978 )

• the optic nerve is barely detectable in adults with only a very limited number of axon bundles present

nervous system

retina ganglion cell degeneration ( J:134978 )

• retinal ganglion cells expressing Pou4f1 are severely reduced in adult retina

• adult mice only have about 5% the number of retinal ganglion cells as do the controls

• genesis of RGCs are not affected as they are present in E13.5 embryos

optic nerve hypoplasia ( J:134978 )

• the optic nerve is barely detectable in adults with only a very limited number of axon bundles present

Allelic Composition	Isl1^tm1Gan/Isl1^tm2Gan Tg(Six3-cre)69Frty/?
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * DBA/2

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal optic nerve innervation ( J:134978 )

• retinal ganglion axons fail to reach the midline at E13.5

• At E15.5, the axons in the optic nerve are less fasciculated and appear to be grouped into two bundles

• in addition, a substantial portion of retinal ganglion cells fail to send out axons or their axons do not exit the optic cup

retina ganglion cell degeneration ( J:134978 )

• retinal ganglion cells expressing Pou4f2 are lost from the center of the retina to the periphery starting at E17.5

• there is a corresponding increase in the number of apoptotic cells in the ganglion cell layer starting at E16.5 and peaking at E17.5

• adult mice only have about a third the number of retinal ganglion cells as do the controls

optic nerve hypoplasia ( J:134978 )

• mice have much thinner optic nerves, optic chiasms and optic tracts

nervous system

abnormal optic tract morphology ( J:134978 )

• mice have much thinner optic nerves, optic chiasms and optic tracts

abnormal optic nerve innervation ( J:134978 )

• retinal ganglion axons fail to reach the midline at E13.5

• At E15.5, the axons in the optic nerve are less fasciculated and appear to be grouped into two bundles

• in addition, a substantial portion of retinal ganglion cells fail to send out axons or their axons do not exit the optic cup

retina ganglion cell degeneration ( J:134978 )

• retinal ganglion cells expressing Pou4f2 are lost from the center of the retina to the periphery starting at E17.5

• there is a corresponding increase in the number of apoptotic cells in the ganglion cell layer starting at E16.5 and peaking at E17.5

• adult mice only have about a third the number of retinal ganglion cells as do the controls

optic nerve hypoplasia ( J:134978 )

• mice have much thinner optic nerves, optic chiasms and optic tracts

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