Phenotypes associated with this allele

• Allele Symbol: Sema3g^{tm1(KOMP)Vlcg}
• Allele Name: targeted mutation 1, Velocigene
• Allele ID: MGI:3797882
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sema3g^tm1(KOMP)Vlcg/Sema3g^tm1(KOMP)Vlcg	involves: C57BL/6NTac	MGI:5897105
cx2	Sema3f^tm1.2Ddg/Sema3f^tm1.2Ddg Sema3g^tm1(KOMP)Vlcg/Sema3g^tm1(KOMP)Vlcg	involves: C57BL/6NTac	MGI:5897108

Genotype
MGI:5897105

hm1

• Allelic Composition: Sema3g^{tm1(KOMP)Vlcg}/Sema3g^{tm1(KOMP)Vlcg}
• Genetic Background: involves: C57BL/6NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal lymphatic vessel morphology ( J:226501 )

• increased lymphatic branching complexity, more so than in Sema3f^tm1.2Ddg homozygotes

• decreased lymphatic width

• however, lymphatic endothelial cell numbers are normal

Genotype
MGI:5897108

cx2

• Allelic Composition: Sema3f^tm1.2Ddg/Sema3f^tm1.2Ddg; Sema3g^{tm1(KOMP)Vlcg}/Sema3g^{tm1(KOMP)Vlcg}
• Genetic Background: involves: C57BL/6NTac

immune system

abnormal lymphatic vessel morphology ( J:226501 )

• synergistic increased lymphatic branching complexity

abnormal lymphatic vessel endothelial cell morphology ( J:226501 )

• increased numbers similar to in Sema3f^tm1.2Ddg homozygotes

• however, lymphatic endothelial cell progenitors exhibit normal migration

lymphatic vessel hyperplasia ( J:226501 )

• hyperplastic lymphatic vasculature in the back skin at E15.5

• however, defective back lymphatic network appears normal from E17.5 onward