Phenotypes associated with this allele

• Allele Symbol: Spta1^sph-4J
• Allele Name: spherocytosis 4 Jackson
• Allele ID: MGI:3798219
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Spta1^sph-4J/Spta1^sph-4J	C57BL/6J-Spta1^sph-4J/Llp	MGI:4437865

Genotype
MGI:4437865

hm1

• Allelic Composition: Spta1^sph-4J/Spta1^sph-4J
• Genetic Background: C57BL/6J-Spta1^sph-4J/Llp

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

enlarged spleen ( J:157766 )

increased spleen weight ( J:157766 )

• massive splenomegaly results from extensive expansion of the red pulp

extramedullary hematopoiesis ( J:157766 )

• extramedullary hematopoietic foci are found in the liver

anemia ( J:157766 )

hemolytic anemia ( J:157766 )

• severe hemolytic anemia with significantly decreased red blood cell count, hemoglobin and hematocrit

abnormal erythrocyte morphology ( J:157766 )

• high numbers of large reticulocytes and small spherocytes, anisocytosis pholychromatophilia due to a high degree of reticulocytosis, poikilocytosis with many bizarrely shaped cells and fragments, increased red blood cell distribution width, and spherocytic red blood cells with membrane loss

decreased erythrocyte cell number ( J:157766 )

• approximately one third of normal red blood cell concentration at 6 weeks of age

decreased hematocrit ( J:157766 )

• approximately one thrid the normal level at 6 weeks of age

decreased hemoglobin content ( J:157766 )

• approximately one thrid the normal level of hemoglobin at 6 weeks of age

decreased mean corpuscular hemoglobin concentration ( J:157766 )

increased mean corpuscular volume ( J:157766 )

anisocytosis ( J:157766 )

anisopoikilocytosis ( J:157766 )

poikilocytosis ( J:157766 )

polychromatophilia ( J:157766 )

spherocytosis ( J:157766 )

reticulocytosis ( J:157766 )

immune system

enlarged spleen ( J:157766 )

increased spleen weight ( J:157766 )

• massive splenomegaly results from extensive expansion of the red pulp

homeostasis/metabolism

increased circulating bilirubin level ( J:157766 )

• approximately three times normal levels

increased circulating iron level ( J:157766 )

• plasma iron levels are significantly higher than normal

increased kidney iron level ( J:157766 )

• extensive iron accumulation in the kidney

increased liver iron level ( J:157766 )

liver/biliary system

increased liver iron level ( J:157766 )

renal/urinary system

increased kidney iron level ( J:157766 )

• extensive iron accumulation in the kidney

growth/size/body

enlarged spleen ( J:157766 )

increased spleen weight ( J:157766 )

• massive splenomegaly results from extensive expansion of the red pulp