mortality/aging
• embryos die before E8.5, for unknown reasons
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Allele Symbol Allele Name Allele ID |
Wdr77tm1Zwan targeted mutation 1, Zhengxin Wang MGI:3798419 |
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Summary |
2 genotypes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• embryos die before E8.5, for unknown reasons
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• parallel alignment of epithelial cells is lost in 6- and 12-month old mice
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• epithelial cells are hyperplastic; prominent nucleoli are observed in nuclei of hyperplastic epithelial cells at 2, 6, and 12 months
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• at 2 months of age, >70% of males display multifocal hyperplasia of dorsal prostate, with hyperplastic epithelial cells filling the prostate glands; hyperplasia is observed at 6 and 12 months in >30% of males
• no hyperplasia is seen in ventral part of prostate
• castrated males do not develop prostatic hyperplasia
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• parallel alignment of epithelial cells is lost in 6- and 12-month old mice
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• epithelial cells are hyperplastic; prominent nucleoli are observed in nuclei of hyperplastic epithelial cells at 2, 6, and 12 months
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• at 2 months of age, >70% of males display multifocal hyperplasia of dorsal prostate, with hyperplastic epithelial cells filling the prostate glands; hyperplasia is observed at 6 and 12 months in >30% of males
• no hyperplasia is seen in ventral part of prostate
• castrated males do not develop prostatic hyperplasia
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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