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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Grip1tm1Rlh
targeted mutation 1, Richard L Huganir
MGI:3798437
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Grip1tm1Rlh/Grip1tm1Rlh involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL MGI:3805833
cx2
 		Grip1tm1Rlh/Grip1tm1Rlh
Grip2tm1Rha/Grip2tm1Rha 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL MGI:3805832


Genotype
MGI:3805833
hm1
Allelic
Composition		 Grip1tm1Rlh/Grip1tm1Rlh
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grip1tm1Rlh mutation (1 available); any Grip1 mutation (93 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:136388 )
N
• cultured cortical neurons show normal long term depression induced by glutamate/depolarization pairing or by phorbol ester chemical treatment following treatment with lentiviral EGFP-IRES-Cre to produce conditional deletion of Grip1




Genotype
MGI:3805832
cx2
Allelic
Composition		 Grip1tm1Rlh/Grip1tm1Rlh
Grip2tm1Rha/Grip2tm1Rha
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grip1tm1Rlh mutation (1 available); any Grip1 mutation (93 available)
Grip2tm1Rha mutation (1 available); any Grip2 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
absent long-term depression ( J:136388 )
• after glutamate/repolarization pairing treatment to induce long term depression, LTD is abolished in cultured neurons from double mutants that were transfected with lentiviral EGFP-IRES-Cre to produce conditional deletion of Grip1
• chemical LTD produced by treatment with a PKC-activating phorbol ester is also abolished in double null mutants in contrast to controls or single Grip1- or Grip2-null mice
• Purkinje cells transfected with a plasmid overexpressing Grip1 show complete rescue of pairing- and chemical-induced LTD; overexpression of Grip2 in Purkinje cells results in only partial rescue of LTD




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
08/02/2024
MGI 6.24 		The Jackson Laboratory