Phenotypes associated with this allele

• Allele Symbol: Grip1^tm1Rlh
• Allele Name: targeted mutation 1, Richard L Huganir
• Allele ID: MGI:3798437
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Grip1^tm1Rlh/Grip1^tm1Rlh	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	MGI:3805833
cx2	Grip1^tm1Rlh/Grip1^tm1Rlh Grip2^tm1Rha/Grip2^tm1Rha	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	MGI:3805832

Genotype
MGI:3805833

hm1

• Allelic Composition: Grip1^tm1Rlh/Grip1^tm1Rlh
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:136388 )

N • cultured cortical neurons show normal long term depression induced by glutamate/depolarization pairing or by phorbol ester chemical treatment following treatment with lentiviral EGFP-IRES-Cre to produce conditional deletion of Grip1

Genotype
MGI:3805832

cx2

• Allelic Composition: Grip1^tm1Rlh/Grip1^tm1Rlh; Grip2^tm1Rha/Grip2^tm1Rha
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

nervous system

absent long-term depression ( J:136388 )

• after glutamate/repolarization pairing treatment to induce long term depression, LTD is abolished in cultured neurons from double mutants that were transfected with lentiviral EGFP-IRES-Cre to produce conditional deletion of Grip1

• chemical LTD produced by treatment with a PKC-activating phorbol ester is also abolished in double null mutants in contrast to controls or single Grip1- or Grip2-null mice

• Purkinje cells transfected with a plasmid overexpressing Grip1 show complete rescue of pairing- and chemical-induced LTD; overexpression of Grip2 in Purkinje cells results in only partial rescue of LTD