Phenotypes associated with this allele

• Allele Symbol: Gria4^tm1.1Mony
• Allele Name: targeted mutation 1.1, Hannah Monyer
• Allele ID: MGI:3798456
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gria4^tm1.1Mony/Gria4^tm1.1Mony	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3804915

Genotype
MGI:3804915

hm1

• Allelic Composition: Gria4^tm1.1Mony/Gria4^tm1.1Mony
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal object recognition memory ( J:136763 )

• compared to wild-type animals, mutants spend less time exploring a new object in the environment, and less time interacting with a rearranged object in the environment

decreased exploration in new environment ( J:136763 )

• exploratory behavior is reduced compared to wild-type

abnormal spatial working memory ( J:136763 )

• moderate impairment is exhibited in rewarded alternation task compared to wild-type

• spatial reference memory is unimpaired in Y maze and standard Morris water maze paradigms

decreased vertical activity ( J:136763 )

• in open field tests, mice spend significantly less time rearing than wild-type

nervous system

abnormal nervous system electrophysiology ( J:136763 )

• power of gamma oscillations in CA3 region hippocampal slices induced by kainate is reduced compared to wild-type

abnormal action potential ( J:136763 )

• interspike intervals in pyramidal cells during gamma oscillations is decreased compared to wild-type

impaired ability to fire action potentials ( J:136763 )

• stronger stimuli are needed to evoke action potential (AP) firing from FS cells; average probability of firing is close to 1 in wild-type cells vs 0.4 in mutant cells

abnormal neuron physiology ( J:136763 )

• CA3 pyramidal cells have more depolarized membrane potential during gamma oscillations and increased input resistance compared to wild-type cells

abnormal excitatory postsynaptic potential ( J:136763 )

• compound EPSPs in interneurons are significantly smaller in slices from mutants than in slices from wild-type; EPSPs also have longer decay times

• EPSP amplitudes in CA3 pyramidal cells are not affected in mutants

abnormal AMPA-mediated synaptic currents ( J:136763 )

• evoked synaptic currents in fast-spiking cells (FS) in CA1 region of hippocampus are reduced compared to wild-type; currents are slightly smaller in calbindin-positive cells

• excitatory drive on parvalbumin-positive (PV) interneurons is significantly reduced at P42

• rise time of currents is not different but decay time in fast-spiking cells is slower

abnormal inhibitory postsynaptic potential ( J:136763 )

• a change in population IPSP expression consisting of decrease in incidence of large, compound IPSPs and an increase in bursts of smaller IPSPs during any given gamma period in CA3 pyramidal cells, resulting in a decrease in IPSP amplitude