Analysis Tools|
Allele Symbol Allele Name Allele ID |
Tbx6tm2Pa targeted mutation 2, Virginia Papaioannou MGI:3798467 |
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| Summary |
4 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• unlike in null mice, direction of embryo turning is similar to controls
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| N |
• unlike in null mice, the direction of heart looping is similar to controls
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• some cilia are shorter and thicker
• most cilia have terminal bulges or balloon like structures
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• direction of turning is completely reversed in 18% (7 of 38) of embryos and partially reversed in an additional 4 embryos
• embryos with reversal of turning direction do not always also have reversal of the direction of heart looping
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• at E9.5 - E10.5, about 40% of embryos show either completely reversed or ventral rather than horizontal looping
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• some cilia are shorter and thicker
• most cilia have terminal bulges or balloon like structures
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• despite decrease in Wnt3a expression in Tbx6 null mice, no defects in somite formation are detected
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| N |
• unlike in Tbx6 null mice, the direction of heart looping is similar to controls
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• image trace analysis suggests an increase in the number of short cilia
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• embryonic cilia on the periphery of Henson's node show a decrease in the proportion of motile cilia with regular motion and an increase in the proportion of erratically moving cilia
• in the pit of the node the proportion of nonmotile and erratically moving cilia is increased and the proportion of motile cilia with regular motion is decreased
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• intracellular calcium asymmetries normally present around the node are absent
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• image trace analysis suggests an increase in the number of short cilia
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• embryonic cilia on the periphery of Henson's node show a decrease in the proportion of motile cilia with regular motion and an increase in the proportion of erratically moving cilia
• in the pit of the node the proportion of nonmotile and erratically moving cilia is increased and the proportion of motile cilia with regular motion is decreased
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/19/2024 MGI 6.24 |
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