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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Opn4tm1(cre)Sapa
targeted mutation 1, Satchidananda Panda
MGI:3798479
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Dscamtm1Pfu/Dscamtm1Pfu
Opn4tm1(cre)Sapa/Opn4+ 		involves: 129 * C57BL/6 MGI:5305038
cn2
 		Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+
Opn4tm1(cre)Sapa/Opn4+ 		involves: 129S * C57BL/6 MGI:3803116


Genotype
MGI:5305038
cn1
Allelic
Composition		 Dscamtm1Pfu/Dscamtm1Pfu
Opn4tm1(cre)Sapa/Opn4+
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dscamtm1Pfu mutation (1 available); any Dscam mutation (106 available)
Opn4tm1(cre)Sapa mutation (0 available); any Opn4 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
abnormal retina ganglion cell morphology ( J:179393 )
• fasiculation and spacing phenotype in melanopsin positive RGCs

nervous system
abnormal axon fasciculation ( J:179393 )
• fasiculation and spacing phenotype in melanopsin positive RGCs
abnormal retina ganglion cell morphology ( J:179393 )
• fasiculation and spacing phenotype in melanopsin positive RGCs

cellular
abnormal axon fasciculation ( J:179393 )
• fasiculation and spacing phenotype in melanopsin positive RGCs




Genotype
MGI:3803116
cn2
Allelic
Composition		 Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+
Opn4tm1(cre)Sapa/Opn4+
Genetic
Background		 involves: 129S * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(HBEGF)Awai mutation (4 available); any Gt(ROSA)26Sor mutation (993 available)
Opn4tm1(cre)Sapa mutation (0 available); any Opn4 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
impaired pupillary reflex ( J:137151 )
• following treatment with diphtheria toxin, light pupilary reflex is lost
decreased retina ganglion cell number ( J:137151 )
• following treatment with diphtheria toxin, 90% of melanopsin retinal ganglion cells are ablated

nervous system
abnormal suprachiasmatic nucleus morphology ( J:137151 )
• following treatment with diphtheria toxin, projections into the suprachiasmatic nucleus are reduced compared to in wild-type mice
decreased retina ganglion cell number ( J:137151 )
• following treatment with diphtheria toxin, 90% of melanopsin retinal ganglion cells are ablated

behavior/neurological
behavior/neurological phenotype ( J:137151 )
N
• despite ablation of melanopsin retinal ganglion cells following treatment with diphtheria toxin, mice exhibit normal image-forming visual responses
impaired pupillary reflex ( J:137151 )
• following treatment with diphtheria toxin, light pupilary reflex is lost
abnormal circardian behavior entrainment ( J:137151 )
• following treatment with diphtheria toxin, mice lose their ability to photo-entrain their circadian rhythm and mice maintain equal activity during light and dark phases unlike in wild-type mice




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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory