Analysis Tools
mortality/aging
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• mice die at around 3 weeks of age (between P19 and P22) with high-frequency breathing
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nervous system
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• between P8 and P14, Schwann cell proliferation is increased
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• the trigeminal and facial/acoustic ganglia are fused
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• the trigeminal and facial/acoustic ganglia are fused
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• the glossopharyngeal and vagal nerves are in abnormal proximity
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• the trigeminal and facial/acoustic ganglia are fused
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• the glossopharyngeal and vagal nerves are in abnormal proximity
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behavior/neurological
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• mice exhibit hindlimb coordination impairments that proceed to difficulties in muscular coordination and in positioning of hindlimbs and forelimbs by P17
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• mice exhibit progressive posterior and anterior paralysis that leads to loss of locomotion by 3 weeks of age
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respiratory system
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• mice exhibit high-frequency breathing at around 3 weeks of age that leads to death
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growth/size/body
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• mice are slightly smaller at birth with different in size increasing during postnatal week 2 and by P15 mice are 80% of wild-type size and further deterioration afterwards
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cellular
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• between P8 and P14, Schwann cell proliferation is increased
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