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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Pvalb-cre)1Mony
transgene insertion 1, Hannah Monyer
MGI:3798581
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Gjd2tm2Kwi/Gjd2tm4Kwi
Tg(Pvalb-cre)1Mony/? 		involves: 129P2/OlaHsd MGI:3835327
cn2
 		Gria1tm2Rsp/Gria1tm2Rsp
Tg(Pvalb-cre)1Mony/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3804917


Genotype
MGI:3835327
cn1
Allelic
Composition		 Gjd2tm2Kwi/Gjd2tm4Kwi
Tg(Pvalb-cre)1Mony/?
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gjd2tm2Kwi mutation (1 available); any Gjd2 mutation (23 available)
Gjd2tm4Kwi mutation (1 available); any Gjd2 mutation (23 available)
Tg(Pvalb-cre)1Mony mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
behavior/neurological phenotype ( J:145292 )
N
• gene disruption occurs in GABAergic neurons but expression is normal in olivary neurons
• responses during eye-blink conditioning is normal




Genotype
MGI:3804917
cn2
Allelic
Composition		 Gria1tm2Rsp/Gria1tm2Rsp
Tg(Pvalb-cre)1Mony/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gria1tm2Rsp mutation (1 available); any Gria1 mutation (65 available)
Tg(Pvalb-cre)1Mony mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
behavior/neurological phenotype ( J:136763 )
N
• mutants show comparable behavior to wild-type in tests for object recognition memory and spatial change
abnormal spatial working memory ( J:136763 )
• moderate impairment is exhibited in rewarded alternation task compared to wild-type
• spatial reference memory is unimpaired in Y maze paradigm

nervous system
abnormal nervous system electrophysiology ( J:136763 )
• power of gamma oscillations in CA3 region hippocampal slices induced by kainate is reduced compared to wild-type
impaired ability to fire action potentials ( J:136763 )
• stronger stimuli are needed to evoke action potential (AP) firing from fast-spiking cells; average probability of firing is close to 1 in wild-type cells vs 0.7 in mutant cells
abnormal excitatory postsynaptic potential ( J:136763 )
• compound EPSPs in interneurons are significantly smaller in slices from mutants than in slices from wild-type; EPSPs also have longer decay times
reduced AMPA-mediated synaptic currents ( J:136763 )
• no reduction in AMPA current is seen at P14, but AMPA-mediated currents are significantly reduced at P42, comparable with the reduction detected in Gria4 mutants at P42




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory