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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Kdm5atm1Kael
targeted mutation 1, William G Kaelin
MGI:3798767
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Kdm5atm1Kael/Kdm5atm1Kael involves: 129S6/SvEvTac * C57BL/6 * FVB/N MGI:3798794
cn2
 		Kdm5atm1Kael/Kdm5atm1Kael involves: 129S6/SvEvTac * C57BL/6 * CBA MGI:5296662
cn3
 		Kdm5atm1Kael/Kdm5atm1Kael
Tg(CAG-cre/Esr1*)5Amc/0 		involves: 129S6/SvEvTac * C57BL/6 * CBA MGI:5296661
cn4
 		Kdm5atm1Kael/Kdm5atm1Kael
Men1tm2.1Mmey/Men1tm2.1Mmey
Tg(Ins2-cre)23Herr/0 		involves: 129S6/SvEvTac * C57BL/6 * CBA/J * FVB/N MGI:5296660


Genotype
MGI:3798794
hm1
Allelic
Composition		 Kdm5atm1Kael/Kdm5atm1Kael
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdm5atm1Kael mutation (1 available); any Kdm5a mutation (76 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:137185 )
• mice are viable and fertile; no other details of analysis provided




Genotype
MGI:5296662
cn2
Allelic
Composition		 Kdm5atm1Kael/Kdm5atm1Kael
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdm5atm1Kael mutation (1 available); any Kdm5a mutation (76 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
early cellular replicative senescence ( J:175625 )
• in mouse embryonic fibroblasts treated with tamoxifen and infected with a retrovirus expressing cre




Genotype
MGI:5296661
cn3
Allelic
Composition		 Kdm5atm1Kael/Kdm5atm1Kael
Tg(CAG-cre/Esr1*)5Amc/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdm5atm1Kael mutation (1 available); any Kdm5a mutation (76 available)
Tg(CAG-cre/Esr1*)5Amc mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
early cellular replicative senescence ( J:175625 )
• in mouse embryonic fibroblasts treated with tamoxifen




Genotype
MGI:5296660
cn4
Allelic
Composition		 Kdm5atm1Kael/Kdm5atm1Kael
Men1tm2.1Mmey/Men1tm2.1Mmey
Tg(Ins2-cre)23Herr/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * CBA/J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdm5atm1Kael mutation (1 available); any Kdm5a mutation (76 available)
Men1tm2.1Mmey mutation (0 available); any Men1 mutation (40 available)
Tg(Ins2-cre)23Herr mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:175625 )
• median survival is 69 weeks

endocrine/exocrine glands
endocrine/exocrine gland phenotype ( J:175625 )
N
• islet proliferation is normal
abnormal pancreatic islet morphology ( J:175625 )
• atypia in 2 of 16 mice at 8 months of age
pancreatic islet hyperplasia ( J:175625 )
• in 1 of 8 mice at 2 months of age
• in 3 of 16 mice at 8 months of age
increased insulinoma incidence ( J:175625 )
• in 2 of 21 mice at 10 months of age

neoplasm
increased insulinoma incidence ( J:175625 )
• in 2 of 21 mice at 10 months of age




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory