mortality/aging
• pups do not survive
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immune system
N |
• thymus cellularity and gamma delta T cells are normal
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• T cell development is partially blocked at DN3 stage
|
• despite normal overall proliferation and apoptosis rates, DN3 cells accumulate more than in wild-type mice
|
• thymocytes are more sensitive to anti-CD3 induced apoptosis than wild-type cells
• thymocytes are at a disadvantage to reconstitute T cell compartments compared to wild-type cells
|
hematopoietic system
• T cell development is partially blocked at DN3 stage
|
• despite normal overall proliferation and apoptosis rates, DN3 cells accumulate more than in wild-type mice
|
• thymocytes are more sensitive to anti-CD3 induced apoptosis than wild-type cells
• thymocytes are at a disadvantage to reconstitute T cell compartments compared to wild-type cells
|