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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ptdss1tm1Jev
targeted mutation 1, Jean Vance
MGI:3798813
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ptdss1tm1Jev/Ptdss1tm1Jev involves: 129S/SvEv * C57BL/6 MGI:3803014
cx2
 		Ptdss1tm1Jev/Ptdss1tm1Jev
Ptdss2Gt(KST314)Byg/Ptdss2Gt(KST314)Byg 		involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 MGI:3803015
cx3
 		Ptdss1tm1Jev/Ptdss1+
Ptdss2Gt(KST314)Byg/Ptdss2Gt(KST314)Byg 		involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 MGI:3803016
cx4
 		Ptdss1tm1Jev/Ptdss1tm1Jev
Ptdss2Gt(KST314)Byg/Ptdss2+ 		involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 MGI:3803017


Genotype
MGI:3803014
hm1
Allelic
Composition		 Ptdss1tm1Jev/Ptdss1tm1Jev
Genetic
Background		 involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptdss1tm1Jev mutation (0 available); any Ptdss1 mutation (38 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:137106 )
N
• despite reduction in phosphatidylserine levels, mice exhibit a normal lifespan

homeostasis/metabolism
abnormal phospholipid level ( J:137106 )
• phosphatidylethanolamine and phosphatidylserine levels in the liver are lower than in wild-type mice

nervous system
nervous system phenotype ( J:137106 )
N
• despite expectations that the deficiency might impair neuronal functions, axonal growth is normal




Genotype
MGI:3803015
cx2
Allelic
Composition		 Ptdss1tm1Jev/Ptdss1tm1Jev
Ptdss2Gt(KST314)Byg/Ptdss2Gt(KST314)Byg
Genetic
Background		 involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptdss1tm1Jev mutation (0 available); any Ptdss1 mutation (38 available)
Ptdss2Gt(KST314)Byg mutation (0 available); any Ptdss2 mutation (74 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:3803016
cx3
Allelic
Composition		 Ptdss1tm1Jev/Ptdss1+
Ptdss2Gt(KST314)Byg/Ptdss2Gt(KST314)Byg
Genetic
Background		 involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptdss1tm1Jev mutation (0 available); any Ptdss1 mutation (38 available)
Ptdss2Gt(KST314)Byg mutation (0 available); any Ptdss2 mutation (74 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:137106 )
N
• despite reduction in phosphatidylserine levels, mice exhibit a normal lifespan

homeostasis/metabolism
abnormal phospholipid level ( J:137106 )
• phospatidylserine levels are reduced by 23% in brain, by 29% in liver, and by 25% in heart compared to in wild-type mice




Genotype
MGI:3803017
cx4
Allelic
Composition		 Ptdss1tm1Jev/Ptdss1tm1Jev
Ptdss2Gt(KST314)Byg/Ptdss2+
Genetic
Background		 involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptdss1tm1Jev mutation (0 available); any Ptdss1 mutation (38 available)
Ptdss2Gt(KST314)Byg mutation (0 available); any Ptdss2 mutation (74 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:137106 )
N
• despite reduction in phosphatidylserine levels, mice exhibit a normal lifespan

homeostasis/metabolism
abnormal phospholipid level ( J:137106 )
• phospatidylserine levels are reduced by 40% in brain, by 29% in liver, and by 33% in heart compared to in wild-type mice




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Send questions and comments to User Support. 		last database update
10/09/2024
MGI 6.24 		The Jackson Laboratory