Analysis Tools
mortality/aging
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• fewer than 50% of mice survive into adulthood
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• mice exhibit a shorter than normal life span that is shorter in female mice than in male mice
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• about half of mice exhibit embryonic or perinatal lethality
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• about half of mice exhibit embryonic or perinatal lethality
• Background Sensitivity: embryonic lethality is more severe on a C57BL/6 background
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immune system
panniculitis
(
J:137101
)
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• mice exhibit dermal and subcutaneous inflammation (panniculitis)
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• hyperproliferation follows stimulation with antiCD3 or anti-CD3 and anti-CD8 antibodies
• CD4+CD25- peripheral T cells exhibit hyperproliferation
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• following stimulation with or anti-CD3 and anti-CD8 antibodies and under Th2 conditions
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• following stimulation with or anti-CD3 and anti-CD8 antibodies and under Th2 conditions
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• following stimulation with or anti-CD3 and anti-CD8 antibodies and under Th2 conditions
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• mice exhibit increased susceptibility to systemic lupus erythematosus that can be transferred by bone marrow transplant
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• mice exhibit an increase in anti-dsDNA, anti-SM. anti-SSA(Ro) and anti-SSB(La) autoantibodies compared to in wild-type mice
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• in more than half of mice and generally limited to the portal regions
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• some mice exhibit lymphocyte-rich chronic inflammatory cell infiltration
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• chronic
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dermatitis
(
J:137101
)
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• chronic spongiotic dermatitis
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homeostasis/metabolism
| N |
• despite an increase in alanine transaminase levels, the level of aspartate aminotransferase and alkaline phosphatase levels are normal
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• following stimulation with or anti-CD3 and anti-CD8 antibodies and under Th2 conditions
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• following stimulation with or anti-CD3 and anti-CD8 antibodies and under Th2 conditions
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• following stimulation with or anti-CD3 and anti-CD8 antibodies and under Th2 conditions
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• 40% of mice exhibit moderate or high urine protein levels with female mice exhibiting a more severe phenotype than male mice
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renal/urinary system
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• mice exhibit global mesangial cell proliferation in the kidney
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• mice exhibit global mesangial cell proliferation in the kidney
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• 40% of mice exhibit moderate or high urine protein levels with female mice exhibiting a more severe phenotype than male mice
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• some mice exhibit lymphocyte-rich chronic inflammatory cell infiltration
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reproductive system
liver/biliary system
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• in more than half of mice and generally limited to the portal regions
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skeleton
craniofacial
growth/size/body
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• body size is two-thirds of normal prior to weaning and after reaching maturity
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hematopoietic system
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• hyperproliferation follows stimulation with antiCD3 or anti-CD3 and anti-CD8 antibodies
• CD4+CD25- peripheral T cells exhibit hyperproliferation
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integument
panniculitis
(
J:137101
)
|
• mice exhibit dermal and subcutaneous inflammation (panniculitis)
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• chronic
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dermatitis
(
J:137101
)
|
• chronic spongiotic dermatitis
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• in some areas mice exhibit immature and decreased hair follicles
• however, frank alopecia is not observed
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acanthosis
(
J:137101
)
skin lesions
(
J:137101
)
|
• mice exhibit periorbital erosion
• from 4 months of age, 75% of mice exhibit skin lesions around the mouth and nose whole 30% of mice exhibit skin lesions on the neck
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cellular
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• mice exhibit global mesangial cell proliferation in the kidney
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• hyperproliferation follows stimulation with antiCD3 or anti-CD3 and anti-CD8 antibodies
• CD4+CD25- peripheral T cells exhibit hyperproliferation
|
|
• mice exhibit global mesangial cell proliferation in the kidney
|
adipose tissue
panniculitis
(
J:137101
)
|
• mice exhibit dermal and subcutaneous inflammation (panniculitis)
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| systemic lupus erythematosus | DOID:9074 |
OMIM:152700 OMIM:300809 OMIM:605480 OMIM:608437 OMIM:609903 OMIM:609939 OMIM:610065 OMIM:610066 OMIM:612254 OMIM:612378 OMIM:613145 OMIM:614420 |
J:137101 | |
