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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Adcy1tm1Ito
targeted mutation 1, Shigeyoshi Itohara
MGI:3798841
Summary 2 genotypes


Genotype
MGI:3802987
cn1
Allelic
Composition
Adcy1tm1Ito/Adcy1tm1.1Ito
Emx1tm1(cre)Ito/Emx1+
Genetic
Background
B6.129P2-Emx1tm1(cre)Ito Adcy1tm1Ito Adcy1tm1.1Ito
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adcy1tm1.1Ito mutation (1 available); any Adcy1 mutation (73 available)
Adcy1tm1Ito mutation (1 available); any Adcy1 mutation (73 available)
Emx1tm1(cre)Ito mutation (1 available); any Emx1 mutation (34 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• despite abnormal barrel cortex morphology, lesion-induced plasticity of the thalamocortical axonal pattern and synaptic release efficacy are normal
• while gross barrel patterning is normal, barrel wall formation is disrupted
• dendritic orientation of layer IV neurons in the barrel cortex is impaired and dendritic span is increased compared to in wild-type micedendritic orientation of layer IV neurons in the barrel cortex is impaired and dendritic span is increased compared to in wild-type mice
• during thalamocorical synapse development
• AMPA receptor mini-excitatory postsynaptic currents of thalamocortical synapses are smaller than in wild-type mice




Genotype
MGI:3802986
cn2
Allelic
Composition
Adcy1tm1Ito/Adcy1tm1.1Ito
Tg(Emx1-cre)3Ito/0
Genetic
Background
B6.Cg-Adcy1tm1Ito Adcy1tm1.1Ito Tg(Emx1-cre)3Ito
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adcy1tm1.1Ito mutation (1 available); any Adcy1 mutation (73 available)
Adcy1tm1Ito mutation (1 available); any Adcy1 mutation (73 available)
Tg(Emx1-cre)3Ito mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• despite abnormal barrel cortex morphology, lesion-induced plasticity of the thalamocortical axonal pattern and synaptic release efficacy are normal
• while gross barrel patterning is normal, barrel wall formation is disrupted
• dendritic orientation of layer IV neurons in the barrel cortex is impaired and dendritic span is increased compared to in wild-type micedendritic orientation of layer IV neurons in the barrel cortex is impaired and dendritic span is increased compared to in wild-type mice
• during thalamocorical synapse development
• AMPA receptor mini-excitatory postsynaptic currents of thalamocortical synapses are smaller than in wild-type mice





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory