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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Adcy1tm1.1Ito
targeted mutation 1.1, Shigeyoshi Itohara
MGI:3798842
Summary 3 genotypes


Genotype
MGI:3802985
hm1
Allelic
Composition		 Adcy1tm1.1Ito/Adcy1tm1.1Ito
Genetic
Background		 B6.129P2-Adcy1tm1.1Ito
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adcy1tm1.1Ito mutation (1 available); any Adcy1 mutation (73 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal thalamus morphology ( J:137123 )
• ventrobasal thalamic barreloids are not as distinct as in wild-type mice
abnormal CNS synaptic transmission ( J:137123 )
• pre- and post-synaptic signaling of thalamocortical neurons is impaired




Genotype
MGI:3802987
cn2
Allelic
Composition		 Adcy1tm1Ito/Adcy1tm1.1Ito
Emx1tm1(cre)Ito/Emx1+
Genetic
Background		 B6.129P2-Emx1tm1(cre)Ito Adcy1tm1Ito Adcy1tm1.1Ito
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adcy1tm1.1Ito mutation (1 available); any Adcy1 mutation (73 available)
Adcy1tm1Ito mutation (1 available); any Adcy1 mutation (73 available)
Emx1tm1(cre)Ito mutation (1 available); any Emx1 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:137123 )
N
• despite abnormal barrel cortex morphology, lesion-induced plasticity of the thalamocortical axonal pattern and synaptic release efficacy are normal
abnormal barrel cortex morphology ( J:137123 )
• while gross barrel patterning is normal, barrel wall formation is disrupted
• dendritic orientation of layer IV neurons in the barrel cortex is impaired and dendritic span is increased compared to in wild-type micedendritic orientation of layer IV neurons in the barrel cortex is impaired and dendritic span is increased compared to in wild-type mice
reduced long-term potentiation ( J:137123 )
• during thalamocorical synapse development
decreased miniature excitatory postsynaptic current amplitude ( J:137123 )
• AMPA receptor mini-excitatory postsynaptic currents of thalamocortical synapses are smaller than in wild-type mice




Genotype
MGI:3802986
cn3
Allelic
Composition		 Adcy1tm1Ito/Adcy1tm1.1Ito
Tg(Emx1-cre)3Ito/0
Genetic
Background		 B6.Cg-Adcy1tm1Ito Adcy1tm1.1Ito Tg(Emx1-cre)3Ito
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adcy1tm1.1Ito mutation (1 available); any Adcy1 mutation (73 available)
Adcy1tm1Ito mutation (1 available); any Adcy1 mutation (73 available)
Tg(Emx1-cre)3Ito mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:137123 )
N
• despite abnormal barrel cortex morphology, lesion-induced plasticity of the thalamocortical axonal pattern and synaptic release efficacy are normal
abnormal barrel cortex morphology ( J:137123 )
• while gross barrel patterning is normal, barrel wall formation is disrupted
• dendritic orientation of layer IV neurons in the barrel cortex is impaired and dendritic span is increased compared to in wild-type micedendritic orientation of layer IV neurons in the barrel cortex is impaired and dendritic span is increased compared to in wild-type mice
reduced long-term potentiation ( J:137123 )
• during thalamocorical synapse development
decreased miniature excitatory postsynaptic current amplitude ( J:137123 )
• AMPA receptor mini-excitatory postsynaptic currents of thalamocortical synapses are smaller than in wild-type mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory