All Phenotypes Gli3<tm1Alj> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Gli3^tm1Alj
targeted mutation 1, Alexandra L Joyner
MGI:3798847

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	En1^tm2(cre)Wrst/? Gli3^tm1Alj/Gli3^tm1Alj	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6	MGI:3803098
cn2	En1^tm2(cre)Wrst/? Gli3^tm1Alj/Gli3^tm1Alj Smo^tm2Amc/Smo^tm2Amc	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6	MGI:3803100
cn3	Gli3^tm1Alj/Gli3^tm1Alj Nkx3-2^tm1(cre)Wez/Nkx3-2⁺	involves: 129S6/SvEvTac * 129S7/SvEvBrd	MGI:5518635
cn4	Gli3^tm1Alj/Gli3^tm1Alj Nkx3-2^tm1(cre)Wez/Nkx3-2⁺ Smo^tm2Amc/Smo^tm2Amc	involves: 129S6/SvEvTac * 129S7/SvEvBrd * 129X1/SvJ	MGI:5518637
cn5	Gli3^tm1Alj/Gli3⁺ Tgif1^tm1Caw/Tgif1^tm1Caw Tgif2^tm1Dwot/Tgif2^tm1Dwot Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺	involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J * CBA	MGI:5791934
cn6	Gli3^tm1Alj/Gli3^tm1Alj Tg(Nes-cre)1Kln/?	involves: 129S6/SvEvTac * C57BL/6 * SJL	MGI:3803099

Allelic Composition	En1^tm2(cre)Wrst/? Gli3^tm1Alj/Gli3^tm1Alj
Genetic Background	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
En1^tm2(cre)Wrst mutation (1 available); any En1 mutation (34 available)
Gli3^tm1Alj mutation (1 available); any Gli3 mutation (81 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:137136 )

N	• isthmus generally normal • superior colliculus normal • inferior colliculus normal

abnormal rhombomere morphology ( J:137136 )

• some Purkinje cells in anterior isthmus region

• Purkinje projections into posterior isthmus region

• dorsal mesencephalon, isthmus, and r1 not distinct at E10.5 and E12.5

• isthmus flexure less prominent

• thickness of ventricular zone increased

enlarged cerebral aqueduct ( J:137136 )

• expanded mesencephalic ventricle at E10.5 and E12.5

abnormal tectum morphology ( J:137136 )

• misshapen

enlarged tectum ( J:137136 )

abnormal hindbrain morphology ( J:137136 )

abnormal cerebellar foliation ( J:137136 )

• abnormal at E18.5

• cerebellum otherwise normal

embryo

abnormal rhombomere morphology ( J:137136 )

• some Purkinje cells in anterior isthmus region

• Purkinje projections into posterior isthmus region

• dorsal mesencephalon, isthmus, and r1 not distinct at E10.5 and E12.5

• isthmus flexure less prominent

• thickness of ventricular zone increased

Allelic Composition	En1^tm2(cre)Wrst/? Gli3^tm1Alj/Gli3^tm1Alj Smo^tm2Amc/Smo^tm2Amc
Genetic Background	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:137136 )

N	• isthmus generally normal • superior colliculus normal • inferior colliculus normal

abnormal rhombomere morphology ( J:137136 )

• some Purkinje cells in anterior isthmus region

• Purkinje projections into posterior isthmus region

• dorsal mesencephalon, isthmus, and r1 not distinct at E10.5 and E12.5

• isthmus flexure less prominent

• thickness of ventricular zone increased

enlarged cerebral aqueduct ( J:137136 )

• expanded mesencephalic ventricle at E10.5 and E12.5

abnormal tectum morphology ( J:137136 )

• misshapen

enlarged tectum ( J:137136 )

abnormal hindbrain morphology ( J:137136 )

abnormal cerebellum morphology ( J:137136 )

abnormal cerebellar foliation ( J:137136 )

• abnormal at E18.5

thin external granule cell layer ( J:137136 )

• external granule cell layer thinner at birth

small cerebellum ( J:137136 )

• at birth

embryo

abnormal rhombomere morphology ( J:137136 )

• some Purkinje cells in anterior isthmus region

• Purkinje projections into posterior isthmus region

• dorsal mesencephalon, isthmus, and r1 not distinct at E10.5 and E12.5

• isthmus flexure less prominent

• thickness of ventricular zone increased

Allelic Composition	Gli3^tm1Alj/Gli3^tm1Alj Nkx3-2^tm1(cre)Wez/Nkx3-2⁺
Genetic Background	involves: 129S6/SvEvTac * 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli3^tm1Alj mutation (1 available); any Gli3 mutation (81 available)
Nkx3-2^tm1(cre)Wez mutation (0 available); any Nkx3-2 mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Gli2 expression, but not Gli3 de-repression, rescues intestinal phenotypes in Smo^tm2Amc/Smo^tm2Amc Nkx3-2^tm1(cre)Wez/Nkx3-2⁺ embryos

mortality/aging

mortality/aging ( J:199664 )

N	• mice are born at the expected Mendelian ratios

digestive/alimentary system

digestive/alimentary phenotype ( J:199664 )

N	• mice exhibit normal intestinal development

Allelic Composition	Gli3^tm1Alj/Gli3^tm1Alj Nkx3-2^tm1(cre)Wez/Nkx3-2⁺ Smo^tm2Amc/Smo^tm2Amc
Genetic Background	involves: 129S6/SvEvTac * 129S7/SvEvBrd * 129X1/SvJ

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Gli2 expression, but not Gli3 de-repression, rescues intestinal phenotypes in Smo^tm2Amc/Smo^tm2Amc Nkx3-2^tm1(cre)Wez/Nkx3-2⁺ embryos

digestive/alimentary system

abnormal digestive system morphology ( J:199664 )

• mice exhibit the same defects as in Nkx3-2^tm1(cre)Wez/Nkx3-2⁺ Smo^m2Amc/Smo^m2Amc mice

Allelic Composition	Gli3^tm1Alj/Gli3⁺ Tgif1^tm1Caw/Tgif1^tm1Caw Tgif2^tm1Dwot/Tgif2^tm1Dwot Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺
Genetic Background	involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3^{Tg(Sox2-cre)1Amc} mutation (5 available); any Edil3 mutation (43 available)
Gli3^tm1Alj mutation (1 available); any Gli3 mutation (81 available)
Tgif1^tm1Caw mutation (1 available); any Tgif1 mutation (52 available)
Tgif2^tm1Dwot mutation (0 available); any Tgif2 mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal forebrain development ( J:183402 )

• reduced Gli3 levels partially rescues ventral forebrain morphology observed in double mutants with less disorganization and partially separated cephalic folds

exencephaly ( J:183402 )

• in half of mice at E18.5

decreased embryonic neuroepithelial cell proliferation ( J:183402 )

• at E10.0

embryo

abnormal cephalic neural fold morphology ( J:183402 )

• partially separated cephalic folds

craniofacial

abnormal olfactory epithelium morphology ( J:183402 )

• partially rescued nasal field separation defect

growth/size/body

abnormal olfactory epithelium morphology ( J:183402 )

• partially rescued nasal field separation defect

respiratory system

abnormal olfactory epithelium morphology ( J:183402 )

• partially rescued nasal field separation defect

taste/olfaction

abnormal olfactory epithelium morphology ( J:183402 )

• partially rescued nasal field separation defect

Allelic Composition	Gli3^tm1Alj/Gli3^tm1Alj Tg(Nes-cre)1Kln/?
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli3^tm1Alj mutation (1 available); any Gli3 mutation (81 available)
Tg(Nes-cre)1Kln mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:137136 )

N	• cerebellum normal

abnormal midbrain-hindbrain boundary morphology ( J:137136 )

• isthmus enlarged

enlarged tectum ( J:137136 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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