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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Igs7tm1(tetO-Apoe)Gaga
transgene insertion 1, George A Gaitanaris
MGI:3798884
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		ApoeTg(rtTA)1Gaga/ApoeTg(rtTA)1Gaga
Igs7tm1(tetO-Apoe)Gaga/0 		involves: 129S1/Sv * C57BL/6J MGI:3802917


Genotype
MGI:3802917
cx1
Allelic
Composition		 ApoeTg(rtTA)1Gaga/ApoeTg(rtTA)1Gaga
Igs7tm1(tetO-Apoe)Gaga/0
Genetic
Background		 involves: 129S1/Sv * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
ApoeTg(rtTA)1Gaga mutation (0 available); any Apoe mutation (158 available)
Igs7tm1(tetO-Apoe)Gaga mutation (0 available); any Igs7 mutation (66 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
increased susceptibility to atherosclerosis ( J:136987 )
• mice exhibit an increased susceptibility to forming athelerosclerotic lesions compared to wild-type mice
• however, treatment with doxycycline reduces susceptibility to normal

homeostasis/metabolism
increased circulating cholesterol level ( J:136987 )
• plasma cholesterol levels are elevated compared to in wild-type mice
• however, treatment with doxycycline returns plasma cholesterol levels to normal




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory